EP 0439527 A4 19911121 - A PROCESS FOR PRODUCING L-PHENYL ACETYL CARBINOL (PAC), AN IMMOBILIZED CELL MASS FOR USE IN THE PROCESS AND A METHOD FOR PREPARING THE CELL MASS
Title (en)
A PROCESS FOR PRODUCING L-PHENYL ACETYL CARBINOL (PAC), AN IMMOBILIZED CELL MASS FOR USE IN THE PROCESS AND A METHOD FOR PREPARING THE CELL MASS
Publication
Application
Priority
US 26062288 A 19881021
Abstract (en)
[origin: WO9004639A1] A process for the production of L-phenyl acetyl carbinol (PAC) is carried out with an immobilized cell mass of non-viable cells of a mutant yeast strain that exhibits resistance to aldehyde inhibition during PAC production. Benzaldehyde and a source of pyruvate are reacted in an aqueous medium in the presence of the immobilized cell mass. Cells in the cell mass contain endogenous pyruvate decarboxylase. Cell walls are chemically crosslinked with polyazetidine and modified to increase permeability to the reactants. A cosolvent for benzaldehyde can be employed to increase PAC production. PAC is useful as an intermediate in the preparation of 1-ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.
IPC 1-7
IPC 8 full level
C12N 1/16 (2006.01); C12N 11/16 (2006.01); C12P 7/26 (2006.01); C12R 1/865 (2006.01)
CPC (source: EP)
C12P 7/26 (2013.01)
Citation (search report)
- No further relevant documents disclosed
- See references of WO 9004639A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9004639 A1 19900503; AU 4501989 A 19900514; CA 2000721 A1 19900421; EP 0439527 A1 19910807; EP 0439527 A4 19911121; JP H04502104 A 19920416
DOCDB simple family (application)
US 8904421 W 19891013; AU 4501989 A 19891013; CA 2000721 A 19891016; EP 89912199 A 19891013; JP 51124589 A 19891013