Global Patent Index - EP 0446299 A4

EP 0446299 A4 19920513 - METHOD FOR SITE-SPECIFICALLY INCORPORATING UNNATURAL AMINO ACIDS INTO PROTEINS

Title (en)

METHOD FOR SITE-SPECIFICALLY INCORPORATING UNNATURAL AMINO ACIDS INTO PROTEINS

Publication

EP 0446299 A4 19920513 (EN)

Application

EP 90901230 A 19891115

Priority

  • US 27345588 A 19881118
  • US 33760189 A 19890413

Abstract (en)

[origin: WO9005785A1] Novel methods are provided for producing proteins, containing unnatural amino acids at specific sites. The methods can utilize modified aminoacyl tRNA's capable of polymerizing a desired unnatural amino acid at unique codons within an mRNA sequence.

IPC 1-7

C12P 19/34; C12P 21/02; C12N 15/01; C07H 21/02

IPC 8 full level

C12P 19/34 (2006.01); A61K 47/48 (2006.01); C07K 1/107 (2006.01); C07K 14/00 (2006.01); C12N 9/86 (2006.01); C12N 15/10 (2006.01); C12N 15/67 (2006.01); C12P 21/02 (2006.01)

CPC (source: EP KR)

A61K 47/68 (2017.07 - EP); A61K 47/6835 (2017.07 - EP); C07K 1/107 (2013.01 - EP); C12N 9/86 (2013.01 - EP); C12N 15/10 (2013.01 - EP); C12N 15/67 (2013.01 - EP); C12P 19/34 (2013.01 - KR); C12P 21/02 (2013.01 - EP)

Citation (search report)

  • [X] US 4568640 A 19860204 - RUBIN HARVEY [US]
  • [Y] US 4687737 A 19870818 - SHARP PHILLIP A [US], et al
  • BIOLOGICAL ABSTRACTS, Philadelphia, PA, US (155th Natl. Meeting of the American Ass. for the Advancement of Science (AAAS), San Francisco, CA (US), 14-19 January 1989); AN BR37:43786/
  • [XP] BIOLOGICAL ABSTRACTS, abstract nr. BR37:43786, Philadelphia, PA, US; 155TH NATIONAL MEETING OF THE AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, San Francisco, California, 14th - 19th January 1989; AAAS PUBL. O (88-30), 1988, page 185; C.J. NOREN et al.: "A general method for site-specifically incorporating unnatural amino acids into proteins"
  • [XP] SCIENCE, vol. 244, 14th April 1989, pages 182-244, AAAS, Washington, DC, US; C.J. NOREN et al.: "A general method for site-specific incorporation of unnatural amino acids into proteins"
  • [XP] TIBS, vol. 14, no. 10, October 1989, pages 400-403, Elsevier Science Publishers, Cambridge, GB; S.J. ANTHONY-CAHILL et al.: "Site-specific mutagenesis with unnatural amino acids"
  • [Y] ANAL. BIOCHEM., vol. 144, no. 1, January 1985, pages 132-141, Academic Press, Inc., NY, US; L.B. SHIH et al.: "A carbene-yielding amino acid for incorporation into peptide photoaffinity reagents"
  • BIOCHEMISTRY, vol. 27, 1988; G. BALDINI et al., pp. 7951-7959/
  • TETRAHEDRON, vol. 40, 1984; T.G. HECKLER et al., pp. 87-94/
  • ACTA CHEMICA SCANDINAVICA B, vol. 37, 1983; J. HEIKKILA et al., pp. 857-864/

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 9005785 A1 19900531; AU 4741290 A 19900612; AU 649217 B2 19940519; EP 0446299 A1 19910918; EP 0446299 A4 19920513; JP H04504651 A 19920820; KR 900702044 A 19901205

DOCDB simple family (application)

US 8905256 W 19891115; AU 4741290 A 19891115; EP 90901230 A 19891115; JP 50128490 A 19891115; KR 900701546 A 19900718