EP 0452412 A4 19920603 - PROCESS FOR THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES
Title (en)
PROCESS FOR THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES
Publication
Application
Priority
US 29322489 A 19890104
Abstract (en)
[origin: WO9007492A1] A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylene tetracyclines is described using a silica-supported heterogeneous rhodium catalyst of general formula (I), wherein R and R' are each selected from hydrogen and C1-C4 alkyl; x is an integer from 1 to 6; Ph is phenyl; y is an integer from 1 to 3; and L is a ligand selected from alkoxysilyl-substituted alkyldiphenyl phosphines. The process stereospecifically produces the alpha epimers at higher yields while using lower rhodium metal levels than prior methods.
IPC 1-7
IPC 8 full level
B01J 31/22 (2006.01); B01J 31/28 (2006.01); C07B 61/00 (2006.01); C07C 231/12 (2006.01); C07C 235/40 (2006.01); C07C 237/26 (2006.01)
CPC (source: EP)
C07C 231/12 (2013.01); C07C 237/26 (2013.01)
Citation (search report)
See references of WO 9007492A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9007492 A1 19900712; CA 2044612 A1 19900705; EP 0452412 A1 19911023; EP 0452412 A4 19920603; JP 2665395 B2 19971022; JP H04504412 A 19920806
DOCDB simple family (application)
US 9000044 W 19900102; CA 2044612 A 19900102; EP 90902446 A 19900102; JP 50243790 A 19900102