Global Patent Index - EP 0453242 A1

EP 0453242 A1 19911023 - Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication.

Title (en)

Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication.

Title (de)

Gen-Sequenzentransfer und -exprimierung bei Zellen des zentralen Nervensystems mit mutierenden Herpes-Simplex-Viren, die Deletionen in Viren-Replikationsgenen enthalten.

Title (fr)

Transfert et expression de séquences géniques dans les cellules du système nerveux central à l'aide de mutants du virus herpès simplex comportant des délétions dans les gènes nécessaires à la réplication virale.

Publication

EP 0453242 A1 19911023 (EN)

Application

EP 91303387 A 19910416

Priority

US 50873190 A 19900416

Abstract (en)

Methods of gene delivery to cells in the central nervous system are disclosed by introducing and expressing gene sequences mediated by herpes simplex virus 1 (HSV-1) vectors with a mutation in a gene for viral replication. <IMAGE>

IPC 1-7

A61K 48/00; C12N 15/86

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C12N 9/40 (2006.01); C12N 15/869 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 25/28 (2018.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2710/16643 (2013.01)

Citation (search report)

  • WO 9002551 A2 19900322 - BIOSOURCE GENETICS CORP [US]
  • WO 9009441 A1 19900823 - GEN HOSPITAL CORP [US]
  • Gene, Vol. 80, No. 1 August 1989, Amsterdam NL, pages 137-144; PALELLA, T.D. et al.: "Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector", the whole document.
  • The New Biologist, Vol. 2, No. 8, August 1990, pages 739-746; CHIOCCA, E.A. et al.: "Transfer and expression of the lacZ gene in rat brain neurons mediated by Herpes Simplex Virus mutants", the whole document.

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0453242 A1 19911023; EP 0453242 B1 19960821; AT E141517 T1 19960915; CA 2039921 A1 19911017; DE 69121452 D1 19960926; DE 69121452 T2 19970102; DK 0453242 T3 19960916; ES 2090243 T3 19961016; GR 3021426 T3 19970131; JP H0795885 A 19950411

DOCDB simple family (application)

EP 91303387 A 19910416; AT 91303387 T 19910416; CA 2039921 A 19910405; DE 69121452 T 19910416; DK 91303387 T 19910416; ES 91303387 T 19910416; GR 960402798 T 19961023; JP 11090791 A 19910416