EP 0454778 A4 19931006 - MOLECULES WITH ANTIBODY COMBINING SITES THAT EXHIBIT STEREOSPECIFIC CATALYSIS
Title (en)
MOLECULES WITH ANTIBODY COMBINING SITES THAT EXHIBIT STEREOSPECIFIC CATALYSIS
Publication
Application
Priority
US 29779889 A 19890117
Abstract (en)
[origin: WO9008185A1] A stereoisomeric analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand and the stereochemistry of the nearby atoms is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds stereospecifically to one stereoisomer of the analog-ligand and also to one stereoisomer of the reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site.
IPC 1-7
IPC 8 full level
C12N 15/02 (2006.01); C07F 9/40 (2006.01); C07F 9/42 (2006.01); C07K 16/00 (2006.01); C12N 5/10 (2006.01); C12N 9/00 (2006.01); C12N 9/18 (2006.01); C12N 9/48 (2006.01); C12N 9/78 (2006.01); C12P 21/06 (2006.01); C12P 21/08 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP KR)
C07F 9/4087 (2013.01 - EP); C07F 9/425 (2013.01 - EP); C07K 16/00 (2013.01 - EP); C12N 5/12 (2013.01 - KR); C12N 9/0002 (2013.01 - EP)
Citation (search report)
- [XD] WO 8809380 A1 19881201 - SCRIPPS CLINIC RES [US]
- See references of WO 9008185A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9008185 A1 19900726; AU 5038290 A 19900813; AU 650846 B2 19940707; CA 2007816 A1 19900717; EP 0454778 A1 19911106; EP 0454778 A4 19931006; FI 913427 A0 19910716; FI 95928 B 19951229; FI 95928 C 19960410; GR 900100025 A 19910607; IE 63274 B1 19950405; IE 900174 L 19900717; JP H04502708 A 19920521; KR 910700334 A 19910314; PT 92884 A 19900731; PT 92884 B 19951229
DOCDB simple family (application)
US 9000269 W 19900112; AU 5038290 A 19900112; CA 2007816 A 19900116; EP 90902870 A 19900112; FI 913427 A 19910716; GR 900100025 A 19900117; IE 17490 A 19900116; JP 50309490 A 19900112; KR 900702060 A 19900917; PT 9288490 A 19900117