EP 0457773 A4 19930310 - N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS
Title (en)
N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS
Publication
Application
Priority
US 30434689 A 19890131
Abstract (en)
[origin: WO9009178A1] A series of N<6>-substituted adenines are disclosed to be antagonists of A2-adenosine receptor-mediated stimulation of adenylate cyclase in A2-adenosine receptors and antagonists of A1-adenosine receptor-mediated inhibition of adenylate cyclase. These compounds are useful in reversal of adenosine-mediated lipolysis, reversal of aenosine-mediated deleterious cardiovascular effects (conduction defects, hypotension), reversal of adenosine-mediated vascular actions in kidney, bronchodilation, antiarrhythmic action, reversal of adeno-mediated relaxation of smooth muscle, anti-narcoleptic action, CNS stimulation, and blockade of adenosine mediated inhibition of neurotransmitter release.
IPC 1-7
IPC 8 full level
C07D 473/18 (2006.01); C07D 473/34 (2006.01)
CPC (source: EP KR)
C07D 473/18 (2013.01 - EP); C07D 473/34 (2013.01 - EP KR)
Citation (search report)
- JP H0045758 B
- JP H006616 B
- [X] TETRAHEDRON vol. 28, no. 3, February 1972, GREAT BRITAIN pages 535 - 547 T. ITAYA ET. AL. 'Purines-6.'
- [X] CHEMICAL ABSTRACTS, vol. 103, no. 3, 22 July 1985, Columbus, Ohio, US; abstract no. 22353q, page 554 ;column 1 ;
- [X] THE JOURNAL OF ORGANIC CHEMISTRY vol. 48, no. 6, 25 March 1983, pages 850 - 855 NICO J. KOS 'Anion Formation and Ring Opening of 9-Substituted Purines in Liquid Ammonia Containing Potassium Amide.'
- See references of WO 9009178A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9009178 A1 19900823; AU 4941490 A 19900905; AU 626983 B2 19920813; EP 0457773 A1 19911127; EP 0457773 A4 19930310; KR 910700253 A 19910314
DOCDB simple family (application)
US 9000210 W 19900116; AU 4941490 A 19900116; EP 90902050 A 19900116; KR 900702209 A 19901005