EP 0460101 A1 19911211 - IMMOBILIZED CYTOKINES.
Title (en)
IMMOBILIZED CYTOKINES.
Title (de)
IMMOBILISIERTE CYTOKINE.
Title (fr)
CYTOKINES IMMOBILISEES.
Publication
Application
Priority
- US 31699289 A 19890224
- US 48225990 A 19900216
Abstract (en)
[origin: WO9009798A1] The present invention provides immobilized cytokines comprising cytokines bound to a solid, preferably biologically inert, support. The bound cytokine, for example IL-2, retains comparable biological activity when bound to the support. Accordingly, the bound cytokine is able to be utilized repeatedly and/or in significantly smaller quantities, as compared to an individual soluble cytokine. Cytokines of the present invention include, but are not limited to, IL-1-alpha, IL-1 beta, rIL-2, IL-2, IL-3, IL-4, IL-6, MuGMCSF, HuGMCSF, HuGCSF, HuEPO, alpha-interferon, gamma-interferon, TNF-alpha, HuILGF-I, HuILGF-II, FGFb, TGF-beta-II, HuEGF, HuPDGF.
Abstract (fr)
L'invention concerne des cytokines immobilisées comprenant des cytokines liées à un solide, de préférence un support biologiquement inerte. La cytokine liée, par exemple IL-2, conserve une activité biologique comparable lorsqu'elle est liée au support. Par conséquent on peut utiliser la cytokine liée de manière répétée et/ou en des quantités significativement inférieures, par rapport à une cytokine individuelle soluble. Les cytokines de l'invention comprennent, sans s'y limiter, IL-1-alpha, IL1-beta, rIL-2, IL-2, IL-3, IL-4, IL-6, MuGMCSF, HuGMCSF, HuGCSF, HuEPO, alpha-interferon, gamma-interferon, TNF-alpha, HuILGF-I, HuILGF-II, FGFB, TGF-beta-II, HuEGF, HuPDGF.
IPC 1-7
A61K 37/00; A61K 37/10; A61K 37/66; A61K 45/05; C07K 17/06; C07K 17/08; C07K 17/10; C07K 17/14; C12N 5/00
IPC 8 full level
C12P 21/00 (2006.01); A61K 9/16 (2006.01); A61K 38/00 (2006.01); A61K 38/21 (2006.01); A61K 38/22 (2006.01); A61K 38/27 (2006.01); C07K 1/113 (2006.01); C07K 14/495 (2006.01); C07K 14/505 (2006.01); C07K 14/52 (2006.01); C07K 14/525 (2006.01); C07K 14/53 (2006.01); C07K 14/535 (2006.01); C07K 14/54 (2006.01); C07K 14/545 (2006.01); C07K 14/55 (2006.01); C07K 14/555 (2006.01); C07K 14/56 (2006.01); C07K 14/565 (2006.01); C07K 14/57 (2006.01); C07K 14/575 (2006.01); C07K 14/65 (2006.01); C07K 17/00 (2006.01); C07K 19/00 (2006.01); C12N 5/00 (2006.01); C12N 5/07 (2010.01); C12N 5/09 (2010.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61K 9/167 (2013.01); C07K 17/00 (2013.01); C12N 5/0025 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9009798 A1 19900907; CA 2047730 A1 19900825; EP 0460101 A1 19911211; EP 0460101 A4 19920415; JP H04503607 A 19920702
DOCDB simple family (application)
US 9001031 W 19900223; CA 2047730 A 19900223; EP 90904576 A 19900223; JP 50521490 A 19900223