EP 0473576 A1 19920311 - SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE.
Title (en)
SHORT THERAPEUTIC dsRNA OF DEFINED STRUCTURE.
Title (de)
KURZE THERAPEUTISCHE RNS EINER BESTIMMTEN STRUKTUR.
Title (fr)
ARN BICATENAIRE THERAPEUTIQUE COURT DE STRUCTURE DEFINIE.
Publication
Application
Priority
US 8902172 W 19890519
Abstract (en)
[origin: WO9014090A1] The present invention relates to the induction of proteins and the activation of enzymes in the cells of living organisms, including human beings. According to the invention, long nucleic and complexes, such as the polyriboinosinate and polycytidylate complexes, are modified to yield short dsRNA of defined sequence. Said short dsRNAs of defined sequence retain the ability to induce proteins and activate enzymes but are not as toxic as long dsRNA.
Abstract (fr)
L'invention concerne l'induction de protéines ainsi que l'activation d'enzymes dans les cellules d'organismes vivants, parmi lesquels l'homme. Selon l'invention on modifie des complexes d'acides nucléiques longs, tels que des complexes de polyriboinosinate et de polycytidylate, afin de produire un ARN bicaténaire court de séquence définie. Lesdits ARN bicaténaires courts de séquence définie conservent la capacité d'induire des protéines et d'activer des enzymes, mais ne sont pas aussi toxiques que les ARN bicaténaires longs.
IPC 1-7
IPC 8 full level
A61K 31/70 (2006.01); A61K 31/00 (2006.01); A61P 43/00 (2006.01); C07H 19/067 (2006.01); C07H 21/02 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01)
CPC (source: EP)
A61K 31/70 (2013.01); A61P 43/00 (2017.12)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9014090 A1 19901129; DK 188991 D0 19911119; EP 0473576 A1 19920311; EP 0473576 A4 19930310; JP H04507083 A 19921210; NO 914529 D0 19911119; NO 914529 L 19920414
DOCDB simple family (application)
US 8902172 W 19890519; DK 188991 A 19911119; EP 89906635 A 19890519; JP 50363789 A 19890519; NO 914529 A 19911119