Global Patent Index - EP 0475352 A1

EP 0475352 A1 19920318 - 3-(1H-Indazol-3-yl)-4-pyridinamines, a process and intermediates for their preparation and their use as medicaments.

Title (en)

3-(1H-Indazol-3-yl)-4-pyridinamines, a process and intermediates for their preparation and their use as medicaments.

Title (de)

3-(1H-Indazol-3-yl)-4-pyridiname, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel.

Title (fr)

(1H-Indazolyl-3)-3 pyridineamines-4, procédé et produits intermédiaires pour leur préparation et leur application comme médicaments.

Publication

EP 0475352 A1 19920318 (EN)

Application

EP 91115280 A 19910910

Priority

US 57975190 A 19900910

Abstract (en)

This Invention relates to 4-(1H-indazol-3-yl)-4-pyridinamines of the formula I <CHEM> where R1 is hydrogen, loweralkyl, arylalkyl or acyl; R2 is hydrogen, loweralkyl or arylalkyl; R3 is hydrogen, loweralkyl or aryl and X is hydrogen, halogen, nitro or amino, or the pharmaceutically acceptable addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention are useful as analgesics and as topical antiinflammatory agents for the treatment of various dermatoses. The invention relates further to intermediates of the formula II <CHEM> where R1, R2 and R3 have the above meaning, which have also analgesic activity, as well as to processes for the preparation of compounds of both formulae.

IPC 1-7

A61K 31/44; C07D 213/73; C07D 213/74; C07D 213/75; C07D 401/04

IPC 8 full level

A61K 31/40 (2006.01); A61K 31/44 (2006.01); A61K 31/4418 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61P 17/00 (2006.01); A61P 25/04 (2006.01); A61P 29/00 (2006.01); C07D 213/73 (2006.01); C07D 213/74 (2006.01); C07D 213/75 (2006.01); C07D 401/04 (2006.01)

CPC (source: EP KR US)

A61P 17/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 29/00 (2017.12 - EP); C07D 213/73 (2013.01 - EP US); C07D 213/75 (2013.01 - EP US); C07D 401/04 (2013.01 - EP KR US)

Citation (search report)

  • [A] EP 0135781 A1 19850403 - HOECHST ROUSSEL PHARMA [US]
  • [A] CHEMICAL ABSTRACTS, vol. 65, no. 10, November 7, 1966, Columbus, Ohio, USA V.E. BONDARENKO et al. "Unsaturated mono- and di- -ketones." column 15261, abstract-no. 15 261h
  • [A] CHEMICAL ABSTRACTS, vol. 102, no. 1, January 7, 1985, Columbus, Ohio, USA WRZECIONO, URSZULA et al. "Azoles. Part II: behavior of 2,7-dinitroindazole in relation to cyclic and ali- phatic amines." page 572, column 1, abstract-no. 6 292t
  • [A] CHEMICAL ABSTRACTS, vol. 60, no. 1, January 6, 1964, Columbus, Ohio, USA K.C. JOSHI AND S. GIRI "Organic pesticides. XIII. Synthesis of some new fluoro ketones and their thiosemi- carbazones." column 470, abstract-no. 470c
  • [A] CHEMICAL ABSTRACTS, vol. 63, no. 7, September 27, 1965, Columbus, Ohio, USA LOREN TSCHETTER "Syn-anti isomerism in unsymmetrically substituted 2,4-dinitrophenyl-hydrazone benzophenones." column 8165, abstract-no. 8 165b
  • [A] CHEMICAL ABSTRACTS, vol. 76, no. 9, February 28, 1972, Columbus, Ohio, USA GINSBURG, V.A. et al. "Polyfluoroazo compounds. IV. Properties of hexafluoro- hydrazomethane." page 349, column 2, abstract-no. 45 849u

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0475352 A1 19920318; EP 0475352 B1 19950607; AT E123493 T1 19950615; AU 640590 B2 19930826; AU 8371691 A 19920312; CA 2050875 A1 19920311; CA 2050875 C 20020716; CS 277691 A3 19920415; CZ 280883 B6 19960417; DE 69110219 D1 19950713; DE 69110219 T2 19951109; DK 0475352 T3 19951016; ES 2074618 T3 19950916; FI 914219 A0 19910906; FI 914219 A 19920311; HU 912901 D0 19920128; HU T59126 A 19920428; IE 67442 B1 19960403; IE 913157 A1 19920311; IL 99434 A0 19920818; IL 99434 A 19950831; JP 3042915 B2 20000522; JP H04247079 A 19920903; KR 100203236 B1 19990615; KR 920006346 A 19920427; NO 913543 D0 19910909; NO 913543 L 19920311; NZ 239692 A 19940126; PL 295728 A1 19930504; PT 98911 A 19920731; PT 98911 B 19990226; US 5051430 A 19910924; ZA 917141 B 19920429

DOCDB simple family (application)

EP 91115280 A 19910910; AT 91115280 T 19910910; AU 8371691 A 19910909; CA 2050875 A 19910906; CS 277691 A 19910909; DE 69110219 T 19910910; DK 91115280 T 19910910; ES 91115280 T 19910910; FI 914219 A 19910906; HU 290191 A 19910909; IE 315791 A 19910909; IL 9943491 A 19910906; JP 22798291 A 19910909; KR 910015736 A 19910910; NO 913543 A 19910909; NZ 23969291 A 19910906; PL 29572891 A 19910909; PT 9891191 A 19910909; US 57975190 A 19900910; ZA 917141 A 19910909