EP 0477295 A4 19921007 - PLATELET AGGREGATION INHIBITORS
Title (en)
PLATELET AGGREGATION INHIBITORS
Publication
Application
Priority
- US 36750989 A 19890616
- US 41802889 A 19891006
- US 48322990 A 19900220
- US 9003417 W 19900615
Abstract (en)
[origin: WO9015620A1] An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K* -(G/Sar)-D wherein K* is a modified lysyl residue of the formula R<1>2 N(CH2)4CHNHCO- wherein each R<1> is independently H, alkyl(1-6C) or at most one R<1> is R<2>-C=NR<3> wherein R<2> is H, alkyl(1-6C), phenyl or benzyl, or is NR<4> in which each R<4> is independently H or alkyl(1-6C) and R<3> is H, alkyl(1-6C), phenyl or benzyl, or R<2>-C=NR<3> is a radical selected from the group consisting of (a), (b), (c) and (d) where m is an integer of 2-3, and each R<5> is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 35/58 (2006.01); A61K 38/02 (2006.01); A61K 38/12 (2006.01); A61K 38/17 (2006.01); A61K 38/36 (2006.01); A61K 38/57 (2006.01); A61P 7/02 (2006.01); C07K 1/14 (2006.01); C07K 1/20 (2006.01); C07K 7/00 (2006.01); C07K 7/06 (2006.01); C07K 7/64 (2006.01); C07K 14/00 (2006.01); C07K 14/435 (2006.01); C07K 14/46 (2006.01); C07K 14/745 (2006.01); C07K 14/75 (2006.01); C07K 14/755 (2006.01); C07K 14/78 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/00 (2006.01); C12P 21/02 (2006.01); C12Q 1/56 (2006.01); G01N 33/86 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP KR US)
A61K 38/12 (2013.01 - EP US); A61K 38/1703 (2013.01 - EP US); A61K 38/54 (2013.01 - KR); A61K 38/57 (2013.01 - EP US); A61P 7/02 (2017.12 - EP); C07K 14/46 (2013.01 - EP US); C07K 14/75 (2013.01 - EP US); C07K 14/755 (2013.01 - EP US); C07K 14/78 (2013.01 - EP US)
Citation (search report)
See references of WO 9015620A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9015620 A1 19901227; AT E146969 T1 19970115; AU 6036990 A 19910108; AU 636159 B2 19930422; CA 2059124 A1 19901217; CA 2059124 C 20020820; CA 2388770 A1 19901227; DE 19975072 I1 20000309; DE 19975072 I2 20110120; DE 69029579 D1 19970213; DE 69029579 T2 19970724; DE 69029579 T3 20060622; DK 0477295 T3 19970707; DK 0477295 T4 20051212; EP 0477295 A1 19920401; EP 0477295 A4 19921007; EP 0477295 B1 19970102; EP 0477295 B2 20051116; EP 0751219 A1 19970102; ES 2097150 T3 19970401; ES 2097150 T5 20060616; FI 104364 B 20000114; FI 915919 A0 19911216; HU 216318 B 19990628; HU 905490 D0 19920330; HU T59835 A 19920728; JP 3281370 B2 20020513; JP H05500750 A 19930218; KR 0180918 B1 19990401; KR 920702627 A 19921006; LU 90488 I2 20000215; NL 990043 I1 20000201; NL 990043 I2 20000403; NO 2000008 I2 20060116; NO 304267 B1 19981123; NO 312965 B1 20020722; NO 914962 D0 19911216; NO 914962 L 19920131; NO 982249 D0 19980515; NO 982249 L 19920131; RU 2156468 C2 20000920; US 5318899 A 19940607; US 5496724 A 19960305; US 5736339 A 19980407; US 5958732 A 19990928
DOCDB simple family (application)
US 9003417 W 19900615; AT 90911002 T 19900615; AU 6036990 A 19900615; CA 2059124 A 19900615; CA 2388770 A 19900615; DE 19975072 C 19900615; DE 69029579 T 19900615; DK 90911002 T 19900615; EP 90911002 A 19900615; EP 96105955 A 19900615; ES 90911002 T 19900615; FI 915919 A 19911216; HU 549090 A 19900615; JP 51036990 A 19900615; KR 910701881 A 19911216; LU 90488 C 19991215; NL 990043 C 19991217; NO 2000008 C 20000906; NO 914962 A 19911216; NO 982249 A 19980515; SU 5010733 A 19900615; US 46398695 A 19950605; US 47424995 A 19950607; US 48322990 A 19900220; US 6713993 A 19930524