Global Patent Index - EP 0478627 A4

EP 0478627 A4 19920819 - CO-EXPRESSION OF HETEROMERIC RECEPTORS

Title (en)

CO-EXPRESSION OF HETEROMERIC RECEPTORS

Publication

EP 0478627 A4 19920819 (EN)

Application

EP 90909432 A 19900515

Priority

  • US 35323589 A 19890516
  • US 41073589 A 19890920
  • US 44633389 A 19891204

Abstract (en)

[origin: WO9014443A1] The invention provides a composition of matter comprising a plurality of procaryotic cells containing diverse combinations of first and second DNA sequences encoding first and second polypeptides that can be expressed and which form heteromeric receptors and at least one of the plurality of procaryotic cells expressing heteromer exhibiting binding activity towards a preselected molecule.

IPC 1-7

C12Q 1/70; C12Q 1/68; C12P 19/34; C12N 15/00; C12Q 1/02

IPC 8 full level

C07K 16/00 (2006.01); C07K 16/46 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 16/00 (2013.01); C07K 16/468 (2013.01); A61K 38/00 (2013.01); C07K 2317/56 (2013.01)

Citation (search report)

  • [Y] WO 8809344 A1 19881201 - CREATIVE BIOMOLECULES INC [US]
  • [Y] WO 8806630 A1 19880907 - GENEX CORP [US]
  • [Y] WO 8901526 A1 19890223 - GENELABS INC [US]
  • [Y] PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 10, 15 May 1989, WASHINGTON US pages 3833 - 3837; Orlandi, R. et al.: 'Cloning Immunoglobulin variable domains for expression by the polymerase chain reaction.'
  • [Y] BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 3, 15 May 1989, DULUTH, MINNESOTA US pages 1250 - 1256; Larrick, J.W. et al.: 'Rapid cloning of rearranged Immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction.'
  • [XP] SCIENCE. vol. 246, 8 December 1989, LANCASTER, PA US pages 1275 - 1281; Huse, W.D. et al.: 'Generation of a large combinatorial library of the Immunoglobulin repertoire in Phage lambda.'
  • [XP] PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 86, August 1989, WASHINGTON US pages 5728 - 5732; Sastry, L. et al.: 'Cloning of the immunological repertoire in Esherichia coli for generation of monoclonal catalytic antibodies : construction of a heavy chain variable region-specific cDNA library'
  • See references of WO 9014443A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 9014443 A1 19901129; AU 5834490 A 19901218; AU 652539 B2 19940901; CA 2057923 A1 19901117; EP 0478627 A1 19920408; EP 0478627 A4 19920819; FI 915411 A0 19911115

DOCDB simple family (application)

US 9002890 W 19900515; AU 5834490 A 19900515; CA 2057923 A 19900515; EP 90909432 A 19900515; FI 915411 A 19911115