EP 0478707 A1 19920408 - IMPROVED PROCESS FOR PREPARING ISEPAMICIN.
Title (en)
IMPROVED PROCESS FOR PREPARING ISEPAMICIN.
Title (de)
VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON ISEPAMICIN.
Title (fr)
PROCEDE AMELIORE DE PREPARATION D'ISEPAMICINE.
Publication
Application
Priority
US 36957889 A 19890621
Abstract (en)
[origin: EP0547031A1] Novel isoserine compounds such as N;O-diformyl-(S)-isoserine and N-formyl-(S)-isoserine are described and used in a process for converting gentamicin B to isepamicin. Active esters are formed by reaction of the isoserine compounds with N-hydroxybenzotriazole, N-hydroxysuccinimide, imidazole, N-hydroxyphthalimide, N-hydroxy-5-norbornene-2,3-dicarboximide and the like in the presence of a coupling agent such as dicyclohexylcarbodiimide.
Abstract (fr)
Selon un procédé amélioré de conversion de gentamicine B en isépamicine, on prépare 3,6'-di-N-formylgentamicine B, on acyle le groupe 1-amine avec un composé de (S)-isosérine à N protégé et on élimine tous les groupes de blocage dans des conditions qui permettent d'obtenir des quantités élevées d'isépamicine. L'invention concerne également un nouvel agent formylant, le 2-formylmercaptobenzothiazole, et des composés intermédiaires.
IPC 1-7
IPC 8 full level
C07D 277/74 (2006.01); C07B 43/06 (2006.01); C07C 233/47 (2006.01); C07C 237/10 (2006.01); C07H 13/04 (2006.01); C07H 15/12 (2006.01); C07H 15/22 (2006.01); C07H 15/236 (2006.01); C07H 15/26 (2006.01)
CPC (source: EP KR)
C07H 15/236 (2013.01 - EP KR); C07H 15/26 (2013.01 - EP); Y02P 20/55 (2015.11 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0405820 A2 19910102; EP 0405820 A3 19910410; EP 0405820 B1 19940413; AT E104310 T1 19940415; AT E152094 T1 19970515; AU 5946390 A 19910108; AU 629960 B2 19921015; CA 2062788 A1 19901222; CA 2062788 C 20011023; CA 2325082 A1 19901222; DE 69008052 D1 19940519; DE 69008052 T2 19940728; DE 69030590 D1 19970528; DE 69030590 T2 19970807; DK 0405820 T3 19940516; DK 0547031 T3 19970520; EP 0478707 A1 19920408; EP 0547031 A1 19930616; EP 0547031 B1 19970423; ES 2063274 T3 19950101; ES 2100380 T3 19970616; FI 915953 A0 19911218; FI 96955 B 19960614; FI 96955 C 19960925; GR 3023942 T3 19970930; HK 1000153 A1 19980102; HK 185096 A 19961011; HU 207338 B 19930329; HU 906641 D0 19920330; HU T59934 A 19920728; JP 2500059 B2 19960529; JP H04502474 A 19920507; JP H0692433 B2 19941116; JP H07133267 A 19950523; KR 920701226 A 19920811; KR 940003496 B1 19940423; NO 177349 B 19950522; NO 177349 C 19950830; NO 915071 D0 19911220; NO 915071 L 19911220; RU 2120444 C1 19981020; WO 9015810 A2 19901227; WO 9015810 A3 19910404
DOCDB simple family (application)
EP 90306657 A 19900619; AT 90306657 T 19900619; AT 93102033 T 19900619; AU 5946390 A 19900619; CA 2062788 A 19900619; CA 2325082 A 19900619; DE 69008052 T 19900619; DE 69030590 T 19900619; DK 90306657 T 19900619; DK 93102033 T 19900619; EP 90917766 A 19900619; EP 93102033 A 19900619; ES 90306657 T 19900619; ES 93102033 T 19900619; FI 915953 A 19911218; GR 970401590 T 19970630; HK 185096 A 19961003; HK 97101672 A 19970820; HU 664190 A 19900619; JP 50955090 A 19900619; JP 9530394 A 19940509; KR 910700196 A 19910220; NO 915071 A 19911220; SU 5010871 A 19900619; US 9003328 W 19900619