Global Patent Index - EP 0480651 A1

EP 0480651 A1 19920415 - Protein for inhibiting collagenstimulated platelet aggregation.

Title (en)

Protein for inhibiting collagenstimulated platelet aggregation.

Title (de)

Protein zur Hemmung der Kollagenstimulierten Blutplätchenaggregation.

Title (fr)

Protéine inhibitrice de l'aggrégation plaquettaire stimulée par la collagène.

Publication

EP 0480651 A1 19920415 (EN)

Application

EP 91309157 A 19911007

Priority

US 59491790 A 19901009

Abstract (en)

A protein isolated from crude Haementeria officinalis extract which blocks stimulation of platelet aggregation by collagen. The protein has a molecular weight of approximately 16,000. A method of isolating the protein and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.

IPC 1-7

A61K 35/62; A61K 37/02; C07K 13/00; C12N 1/21; C12N 15/12; C12N 15/74; C12P 21/02; C12Q 1/68

IPC 8 full level

A61K 35/62 (2006.01); A61K 38/00 (2006.01); A61K 38/36 (2006.01); A61P 7/02 (2006.01); C07K 1/22 (2006.01); C07K 1/30 (2006.01); C07K 14/435 (2006.01); C07K 14/815 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12R 1/865 (2006.01)

CPC (source: EP US)

A61P 7/02 (2017.12 - EP); C07K 14/43536 (2013.01 - EP US); C07K 14/815 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); Y10S 530/855 (2013.01 - EP US)

Citation (search report)

  • [A] WO 8700860 A1 19870212 - BIOPHARM LTD [GB], et al
  • [A] CHEMICAL ABSTRACTS, vol. 107, no. 23, 7 December 1987, Columbus, Ohio, US; abstract no. 211673N, I. P. BASKOVA ET AL.: "MECHANISMS OF INHIBITION OF VASCULAR-PLATELET HEMOSTASIS BY SALIVARY GLAND SECRETION OF THE MEDICINAL LEECH HIRUDO MEDICINALIS." page 33; & BIOKHIMIYA (MOSCOW) vol. 52, no. 9, 1987, pages 1461 - 1468
  • [A] GENE, vol. 75, no. 1, 30 January 1989, AMSTERDAM (NL) pages 47 - 57; J. H. HAN ET AL.: "CLONING AND EXPRESSION OF cDNA ENCODING ANTISTASIN, A LEECH-DERIVED PROTEIN HAVING ANTI-COAGULANT AND ANTI-METASTATIC PROPERTIES."

Designated contracting state (EPC)

CH DE FR GB IT LI NL

DOCDB simple family (publication)

EP 0480651 A1 19920415; CA 2052486 A1 19920410; JP H0586098 A 19930406; JP H0772197 B2 19950802; US 5324715 A 19940628

DOCDB simple family (application)

EP 91309157 A 19911007; CA 2052486 A 19910930; JP 26001491 A 19911008; US 4454793 A 19930407