Global Patent Index - EP 0491675 A1

EP 0491675 A1 19920624 - Improvements relating to growth factors.

Title (en)

Improvements relating to growth factors.

Title (de)

Verbesserungen an Wachstumfaktoren.

Title (fr)

Améliorations relatives aux facteurs de croissance.

Publication

EP 0491675 A1 19920624 (EN)

Application

EP 92101700 A 19850130

Priority

  • EP 92101700 A 19850130
  • GB 8402379 A 19840130
  • GB 8500538 A 19850109

Abstract (en)

Neoplastic and other diseases can be diagnosed by assaying a human test sample e.g. body fluid, tissue or cultured tumour explant cells, for structurally altered or abnormally expressed growth factor receptors or for the mRNA transcripts of genes which encode them. Antibodies capable of binding a predetermined amino acid sequence within the EGF receptor are also useful in diagnosis and therapy as are conjugates of an immunogenic polymer bound to a polypeptide fragment of EGF receptor. DNA and RNA encoding EGF receptor or fragments thereof are also described.

IPC 1-7

A61K 39/395; A61K 49/00; C07K 7/04; C07K 15/00; C12P 21/00; C12Q 1/68; G01N 33/574

IPC 8 full level

A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); C07K 7/04 (2006.01); C07K 14/71 (2006.01); C07K 16/28 (2006.01); C12P 21/00 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01); G01N 33/74 (2006.01); H01L 21/027 (2006.01); A61K 38/00 (2006.01)

IPC 8 main group level

C12N (2006.01)

CPC (source: EP US)

A61K 47/6849 (2017.07 - EP US); A61K 49/00 (2013.01 - EP US); C07K 14/71 (2013.01 - EP US); C07K 16/2863 (2013.01 - EP US); C12Q 1/6886 (2013.01 - EP US); G01N 33/5748 (2013.01 - EP US); G01N 33/74 (2013.01 - EP US); H01L 21/0276 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2317/34 (2013.01 - EP US); C12Q 2600/156 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US); Y10S 436/813 (2013.01 - EP US); Y10S 436/815 (2013.01 - EP US); Y10S 436/817 (2013.01 - EP US)

Citation (search report)

  • [T] NATURE, vol. 311, no. 5985, 4th October 1984, pages 414-416, London, GB; T. HUNTER: "The epdidermal growth factor receptor gene and its products"
  • [XP] NATURE, vol. 309, no. 5967, 31st May 1984, pages 418-425, London, GB; A. ULLRICH et al.: "Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells"
  • [XP] NATURE, vol. 309, no. 5971, 28th June 1984, pages 806-810, London, GB; Y.H. XU et al.: "Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells"
  • [XP] PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE, vol. 81, no. 19, October 1984, pages 5911-5915, US; I. LAX et al.: "Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system"
  • [XP] NATURE, vol. 307, no. 5951, 9th February 1984, pages 521-527, London, GB; J. DOWNWARD et al.: "Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences"
  • [XP] SCIENCE, vol. 224, no. 4651, 25th May 1984, pages 843-848; C. LIN et al.: "Expression cloning of human EGF receptor complementary DNA: GENE amplification and three related messenger RNA products in A431 cells"
  • [A] PROC. NATL. ACAD. SCI. USA, vol. 80, no. 21, November 1983, pages 6451-6455; J. HAPGOOD et al.: "Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3)"
  • [A] CHEMICAL ABSTRACTS, vol. 99, no. 19, 7th November 1983, page 455, abstract no. 156453e, Columbus, Ohio, US; D. WATERFIELD et al.: "Anti-epidermal-growth factor receptor monoclonal antibodies", & CELL BIOL. INT. REP. 1983, 7(7), 535-6
  • [A] PROC. NATL. ACAD. SCI. USA, vol. 79, no. 16, August 1982, pages 5026-5030; C. CARLIN et al.: "Identity of human epidermal growth factor (EGF) receptor with glycoproteine SA-7: Evidence for differential phosphorylation of two components of the EGF receptor from A431 cells"
  • [A] NATURE, vol. 294, no. 5387, 12th November 1981, pages 171-173; I. TROWBRIDGE et al.: "Anti-transferrin receptor monoclonal antibody and toxin-antibody conjugates affect growth of human tumour cells"

Designated contracting state (EPC)

AT BE CH DE FR GB LI LU NL SE

DOCDB simple family (publication)

WO 8503357 A1 19850801; AT E97498 T1 19931215; AU 3934085 A 19850809; DE 3587657 D1 19931223; EP 0171407 A1 19860219; EP 0171407 B1 19931118; EP 0491675 A1 19920624; IL 74201 A0 19850430; US 4933294 A 19900612

DOCDB simple family (application)

GB 8500045 W 19850130; AT 85900716 T 19850130; AU 3934085 A 19850130; DE 3587657 T 19850130; EP 85900716 A 19850130; EP 92101700 A 19850130; IL 7420185 A 19850130; US 78395185 A 19850930