Global Patent Index - EP 0494256 A4

EP 0494256 A4 19920812 - EVALUATIVE MEANS FOR DETECTING INFLAMMATORY REACTIVITY AND FOR PREDICTING RESPONSE TO STRESS

Title (en)

EVALUATIVE MEANS FOR DETECTING INFLAMMATORY REACTIVITY AND FOR PREDICTING RESPONSE TO STRESS

Publication

EP 0494256 A4 19920812 (EN)

Application

EP 90915568 A 19900925

Priority

  • US 41229489 A 19890925
  • US 42279189 A 19891018

Abstract (en)

[origin: WO9104479A1] The present invention relates to a diagnostic test for testing susceptibility of individuals to inflammatory diseases such as rheumatoid arthritis and to means to evaluate potential treatment of arthritis with therapeutic agents directed at the central nervous system (CNS), designed to by-pass the CNS defect. The invention also provides means for evaluating and predicting response to stress in individuals. A counter-regulatory feedback loop exists between the immune and central nervous systems, in which the immune or pro-inflammatory mediators stimulate corticotropin-releasing hormone (CRH) activation of the hypothalamic-pituitary-adrenal (HPA) axis hormonal cascade. The resultant increase in plasma glucocorticoids serves to restrain and limit the intensity of the inflammatory-immune response, through the potent immunosuppressive/anti-inflammatory actions of the glucocorticoids.

IPC 1-7

G01N 1/00; G01N 33/48; A61K 37/66; A61K 45/05

IPC 8 full level

A61K 31/135 (2006.01); A61K 31/495 (2006.01); A61K 31/57 (2006.01); A61K 38/00 (2006.01); A61K 38/095 (2019.01); A61K 38/22 (2006.01); A61K 38/27 (2006.01); A61K 45/00 (2006.01); A61P 29/00 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/74 (2006.01)

CPC (source: EP)

A61K 38/095 (2018.12); A61K 38/2006 (2013.01); A61K 38/2228 (2013.01); A61K 38/31 (2013.01); A61P 29/00 (2017.12); G01N 33/5091 (2013.01); G01N 2800/102 (2013.01)

Citation (search report)

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 9104479 A1 19910404; AU 648274 B2 19940421; AU 6537490 A 19910418; CA 2067123 A1 19910326; EP 0494256 A1 19920715; EP 0494256 A4 19920812; JP H04504760 A 19920820

DOCDB simple family (application)

US 9005457 W 19900925; AU 6537490 A 19900925; CA 2067123 A 19900925; EP 90915568 A 19900925; JP 51435090 A 19900925