EP 0496852 A1 19920805 - NOVEL ADENOSINE DERIVATIVES, THEIR PRODUCTION AND USE.
Title (en)
NOVEL ADENOSINE DERIVATIVES, THEIR PRODUCTION AND USE.
Title (de)
NEUE ADENOSIN-DERIVATE, DEREN HERSTELLUNG UND VERWENDUNG.
Title (fr)
NOUVEAUX DERIVES DE L'ADENOSINE, PREPARATION ET UTILISATION.
Publication
Application
Priority
DE 4025879 A 19900816
Abstract (en)
[origin: WO9203463A1] The invention relates to adenosine-2',3'-carbonates of the formula (I) in which R1?-R3? and X have the significance explained in claim (1), process for producing them and their use in the treatment of increased blood pressure, to protect against cardiac insufficiency, for peripheral and coronary vasodilation, to reduce thrombus formation, to protect the blood vessel endothel, reduce blood lipids, improve glucose tolerance and reduce the plasma insulin level, as an anti-arrhythmic in supraventricular tachycardia and also to treat $i(claudicatio intermitens) and Reynaud's disease.
Abstract (fr)
On revendique des adénosines-2',3'-carbonates de formule (I) dans laquelle R1-R3 et X possèdent la notation indiquée dans la revendication (1), des procédés pour leur préparation et leur utilisation pour le traitement des élévations de la pression artérielle, la protection contre les insuffisances cardiaques, la vasodilatation périphérique et coronaire, la réduction de la formation de thrombi, la protection de l'endothélium vasculaire, l'abaissement de la proportion de lipides dans le sang, l'amélioration de la tolérance au glucose et l'abaissement du taux de plasma-insuline, comme anti-arythmiques dans les tachycardies supraventriculaires, ainsi que pour le traitement de la claudication intermittente et de la maladie de Reynaud.
IPC 1-7
IPC 8 full level
A61K 31/70 (2006.01); A61K 31/7042 (2006.01); A61K 31/7052 (2006.01); A61K 31/7076 (2006.01); A61P 3/06 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 9/14 (2006.01); C07H 19/16 (2006.01)
CPC (source: EP)
A61P 3/06 (2017.12); A61P 9/00 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 9/14 (2017.12); C07H 19/16 (2013.01)
Citation (search report)
See references of WO 9203463A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9203463 A1 19920305; AU 638600 B2 19930701; AU 8303291 A 19920317; CA 2064869 A1 19920217; CS 97892 A3 19920812; DE 4025879 A1 19920220; EP 0496852 A1 19920805; FI 921691 A0 19920415; HU 9201080 D0 19920629; HU T60504 A 19920928; JP H05502889 A 19930520; PL 294368 A1 19930628; TW 197448 B 19930101
DOCDB simple family (application)
CH 9100170 W 19910813; AU 8303291 A 19910813; CA 2064869 A 19910813; CS 97892 A 19920401; DE 4025879 A 19900816; EP 91913964 A 19910813; FI 921691 A 19920415; HU 108092 A 19910813; JP 51311391 A 19910813; PL 29436891 A 19910813; TW 80109279 A 19911126