Global Patent Index - EP 0500653 A4

EP 0500653 A4 19950823 - INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE

Title (en)

INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE

Publication

EP 0500653 A4 19950823 (EN)

Application

EP 90916628 A 19901012

Priority

  • US 42909789 A 19891031
  • US 42909889 A 19891031
  • US 42909989 A 19891031
  • US 42910089 A 19891031
  • US 44279889 A 19891129

Abstract (en)

[origin: WO9106548A1] Disclosed is a compound containing a 2-amino-7-(R)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein R is cyclohexenyl, cyclohexyl, or -CH2-R1, and wherein R1 is an optionally substituted heteroalicyclic, pyridinyl or alicyclic group. Also disclosed is a compound of formula (I), wherein R<1> is H, NH2, or OCH3, R<2> is an optionally substituted cyclic group of 5-7 carbon atoms optionally containing one or more heteroatoms, R<3> and R<4> are independently H or C1-4 alkyl, m is 0-4, n is 0-6, p is 0-1, X is CN, CSNH2, PO(OH)2, COOH, SO2NH2, NH2, OH CNHNH2, tetrazole, or triazole, COR<5> where R<5> is C1-4 alkyl, CF3, NH2, or OC1-4 alkyl, and Y is O or NH.

IPC 1-7

C07D 487/00; C07D 265/30; C07D 237/00; C07D 241/00; C07D 211/70; C07D 231/10; C07F 9/02; A61K 31/505; A61K 31/535; A61K 31/495

IPC 8 full level

A61K 31/505 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07C 255/17 (2006.01); C07C 255/25 (2006.01); C07C 255/31 (2006.01); C07C 255/35 (2006.01); C07C 255/40 (2006.01); C07C 255/42 (2006.01); C07D 207/34 (2006.01); C07D 487/04 (2006.01); C07F 9/6561 (2006.01)

CPC (source: EP)

A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07C 255/31 (2013.01); C07C 255/35 (2013.01); C07C 255/40 (2013.01); C07C 255/42 (2013.01); C07D 207/34 (2013.01); C07D 487/04 (2013.01)

Citation (search report)

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 9106548 A1 19910516; AU 654264 B2 19941103; AU 6712590 A 19910531; CA 2072123 A1 19910501; CA 2072123 C 20010612; EP 0500653 A1 19920902; EP 0500653 A4 19950823; FI 103972 B1 19991029; FI 103972 B 19991029; FI 921900 A0 19920428; FI 921900 A 19920428; HU 9201450 D0 19920928; HU T61765 A 19930301; JP 2866478 B2 19990308; JP H05504551 A 19930715; LV 10100 A 19940510; LV 10100 B 19950820; NO 301423 B1 19971027; NO 921679 D0 19920429; NO 921679 L 19920617

DOCDB simple family (application)

US 9005756 W 19901012; AU 6712590 A 19901012; CA 2072123 A 19901012; EP 90916628 A 19901012; FI 921900 A 19920428; HU 145090 A 19901012; JP 51555090 A 19901012; LV 930342 A 19930514; NO 921679 A 19920429