EP 0503055 A4 19940216 -
Publication
Application
Priority
US 57850690 A 19900906
Abstract (en)
[origin: WO9204049A1] Peptides having at least seven amino acids, preferably up to 20 amino acids, and most preferably 7 to 9 amino acids, comprising an amino acid sequence which corresponds to positions 180-186 of the Mycobacterium tuberculosis protein hsp 65 having the formula TFGLQLE, but differing therefrom by one to three amino acid substitutions in the positions 181-183, are disclosed. These peptides inhibit antigen recognition by T lymphocytes, such as recognition of hsp 65, and are capable of protecting a subject from an immune-related disease, such as autoimmune arthritis and to prevent rejection of a transplanted organ or tissue. Single amino acid substitutions, in particular with alanine, at positions corresponding to hsp 65 positions 183 and 181 are preferred. T cell lines specific for the above peptides and their use in treating or preventing immune-related disease is also disclosed.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/04 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01); C07K 14/00 (2006.01); C07K 14/35 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP)
A61P 37/00 (2017.12); A61P 37/06 (2017.12); C07K 14/35 (2013.01); C07K 14/4703 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [X] MANNIE ET AL: "ENCEPHALITOGENIC AND PROLIFERATIVE RESPONSES OF LEWIS RAT LYMPHOCYTES DISTUINGUISHED BY POSITION 75- AND 80-SUBSTITUTED PEPTIDES OF MYELIN BASIC PROTEIN", THE JOURNAL OF IMMUNOLOGY, vol. 142, 1989, BALTIMORE,USA, pages 2608 - 2616, XP002207806
- [X] DUNKLEY ET AL: "AMINO ACID SEQUENCE OF THE SMALLER BASIC PROTEIN FROM RAT BRAIN MYELIN", THE BIOCHEMICAL JOURNAL, vol. 141, 1974, LONDON,GB, pages 243 - 255
- [X] SCHAICH ET AL: "CLONED PROTEOLIPID PROTEIN AND MYELIN BASIC PROTEIN CDNA", BIOLOGICAL CHEMISTRY HOPPE-SEYLER, vol. 367, 1986, BERLIN,DE, pages 825 - 834, XP008009587
- [DA] BEN-NUN ET AL: "EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) MEDIATED BY T CELL LINES:PROCESS OF SELECTION OF LINES AND CHARACTERIZATION OF THE CELLS", THE JOURNAL OF IMMUNOLOGY, vol. 129, 1982, BALTIMORE,USA, pages 303 - 308
- See references of WO 9204049A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9204049 A1 19920319; AU 650065 B2 19940609; AU 8755991 A 19920330; CA 2071896 A1 19920307; EP 0503055 A1 19920916; EP 0503055 A4 19940216; IL 99429 A0 19920818; JP H05507501 A 19931028; NZ 239699 A 19931125; ZA 917097 B 19920930
DOCDB simple family (application)
US 9106434 W 19910905; AU 8755991 A 19910905; CA 2071896 A 19910905; EP 91918631 A 19910905; IL 9942991 A 19910906; JP 51784991 A 19910905; NZ 23969991 A 19910906; ZA 917097 A 19910906