EP 0505543 A1 19920930 - NOVEL p-SUBSTITUTED PHENYL 4-OXYBUTANE AMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.
Title (en)
NOVEL p-SUBSTITUTED PHENYL 4-OXYBUTANE AMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.
Title (de)
P-SUBSTITUIERTE 4-PHENYL-4-OXYBUTANAMINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN.
Title (fr)
NOUVEAUX DERIVES p-SUBSTITUES DE PHENYL 4-OXYBUTANE AMINE, LEURS PROCEDES DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT.
Publication
Application
Priority
FR 9012562 A 19901017
Abstract (en)
[origin: WO9206977A1] The present invention concerns organic chemistry and more particulary therapeutic chemistry. It has as its subject novel (4-substituted phenyl) 4-oxy 1-aminobutane of the general formula (I) in which X is a nitrogen atom or >CH-NH, and R is a cyclic substituent chosen from the group comprising a) a xanthic substituent, b) a benzimidazolic substituent, as well as salts and optic isomers of the compounds of formula (I). The invention also concerns processes for obtaining the compounds of formula (I) and pharmaceutical compositions containing, as active ingredient, at least one compound of formula (I) or one of its salts with a mineral or organic acid.
Abstract (fr)
La présente invention se rapporte au domaine de la chimie organique et plus particulièrement de la chimie thérapeutique. Elle a pour objet de nouveaux dérivés (4-substitué phényl) 4-oxy 1-aminobutane de formule générale (I) dans laquelle X est un atome d'azote ou >CH-NH, et R est un substituant cyclique choisi dans le groupe constitué par a) un substituant Xanthique, b) un substituant benzimidazolique ainsi que les sels et les isomères optiques des composés de formule (I). L'invention concerne aussi des procédés pour obtenir les composés de formule (I) ainsi que les compositions pharmaceutiques renfermant à titre de principe actif au moins un composé de formule (I) ou un de ses sels avec un acide minéral ou organique.
IPC 1-7
A61K 31/445; A61K 31/495; A61K 31/52; C07D 235/30; C07D 401/12; C07D 473/08
IPC 8 full level
A61K 31/415 (2006.01); A61K 31/4184 (2006.01); A61K 31/4427 (2006.01); A61K 31/4433 (2006.01); A61K 31/445 (2006.01); A61K 31/4468 (2006.01); A61K 31/454 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/52 (2006.01); A61K 31/522 (2006.01); A61P 11/14 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07D 211/46 (2006.01); C07D 235/30 (2006.01); C07D 295/08 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 409/04 (2006.01); C07D 473/08 (2006.01)
IPC 8 main group level
C07D (2006.01)
CPC (source: EP US)
A61P 11/14 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 235/30 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 409/04 (2013.01 - EP US); C07D 473/08 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9206977 A1 19920430; AP 282 A 19930908; AP 9100328 A0 19911031; BG 60680 B1 19951229; BG 96487 A 19931224; BR 9106188 A 19930316; CA 2071911 A1 19920418; CZ 182292 A3 19930113; EP 0505543 A1 19920930; FI 922773 A0 19920616; FI 922773 A 19920616; FR 2668150 A1 19920424; FR 2668150 B1 19941118; FR 2670783 A1 19920626; FR 2670783 B1 19941118; HU 9202176 D0 19921028; HU T61297 A 19921228; IE 913636 A1 19920422; IL 99776 A0 19920818; JP H05503298 A 19930603; KR 927003589 A 19921218; MA 22321 A1 19920701; NO 922358 D0 19920616; NO 922358 L 19920811; NZ 240274 A 19950726; OA 09835 A 19940815; PL 169022 B1 19960531; PL 169452 B1 19960731; PT 99266 A 19920831; RO 108241 B1 19940331; US 5461059 A 19951024; ZA 918282 B 19920729
DOCDB simple family (application)
FR 9100811 W 19911017; AP 9100328 A 19911017; BG 9648792 A 19920616; BR 9106188 A 19911017; CA 2071911 A 19911017; CS 182292 A 19920615; EP 91918443 A 19911017; FI 922773 A 19920616; FR 9012562 A 19901017; FR 9112515 A 19911011; HU 217692 A 19911017; IE 363691 A 19911017; IL 9977691 A 19911017; JP 51770591 A 19911017; KR 920701452 A 19920619; MA 22603 A 19911016; NO 922358 A 19920616; NZ 24027491 A 19911017; OA 60229 A 19920617; PL 29502991 A 19911017; PL 31056291 A 19911017; PT 9926691 A 19911017; RO 92081891 A 19911017; US 86181693 A 19930326; ZA 918282 A 19911017