EP 0509056 A1 19921021 - TARGET-SPECIFIC, CYTOTOXIC, RECOMBINANT PSEUDOMONAS EXOTOXIN.
Title (en)
TARGET-SPECIFIC, CYTOTOXIC, RECOMBINANT PSEUDOMONAS EXOTOXIN.
Title (de)
ZIELSPEZIFISCHE, ZYTOTOXISCHE, REKOMBINANTE PSEUDOMONAS EXOTOXINE.
Title (fr)
EXOTOXINE DE PSEUDOMONASE, CYTOTOXIQUE, RECOMBINEE SPECIFIQUE A UNE CIBLE.
Publication
Application
Priority
US 45963590 A 19900102
Abstract (en)
[origin: WO9109949A1] A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III at the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth.
Abstract (fr)
Exotoxine de Pseudomonas, cytotoxique, recombinée spécifique à une cible. Lesdites toxines sont obtenues par insertion de molécules de reconnaissance spécifiques sur des sites de clonage spécifiques, dans au moins le domaine III au niveau de la terminaison carboxyle de la molécule PE. Diverses modifications de la terminaison carboxyle de la molécule PE augmentant la cytotoxicité, sont présentées.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 14/00 (2006.01); C07K 14/21 (2006.01); C07K 14/495 (2006.01); C07K 14/73 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12N 15/31 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01); C12R 1/38 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/21 (2013.01); C07K 14/495 (2013.01); C07K 14/70514 (2013.01); C07K 16/2866 (2013.01); A61K 38/00 (2013.01); C07K 2317/77 (2013.01); C07K 2319/00 (2013.01); C07K 2319/034 (2013.01); C07K 2319/55 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9109949 A1 19910711; AU 644139 B2 19931202; AU 7242491 A 19910724; CA 2072891 A1 19910703; CA 2072891 C 19991221; EP 0509056 A1 19921021; EP 0509056 A4 19930217; JP 2610740 B2 19970514; JP H05502032 A 19930415
DOCDB simple family (application)
US 9007421 W 19901227; AU 7242491 A 19901227; CA 2072891 A 19901227; EP 91904103 A 19901227; JP 50433390 A 19901227