EP 0509354 A2 19921021 - Amino acid derivatives.
Title (en)
Amino acid derivatives.
Title (de)
Aminosäurederivate.
Title (fr)
Dérivés d'aminoacides.
Publication
Application
Priority
- CH 52392 A 19920220
- CH 114691 A 19910417
Abstract (en)
The compounds of the formula <IMAGE> in which A, R<1>, R<2>, R<3>, R<4> and R<5> have the meaning given in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates and pharmaceutically utilisable salts thereof inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be prepared by various processes known per se.
Abstract (de)
Die Verbindungen der Formel <IMAGE> worin A, R¹, R², R³ R<4> und R<5> die in Anspruch 1 angegebene Bedeutung besitzen, in Form von optisch reinen Diastereomeren, Diastereomerengemischen, diastereomeren Racematen oder Gemischen von diastereomeren Racematen sowie pharmazeutisch verwendbare Salze davon hemmen die Wirkung des natürlichen Enzyms Renin und können demnach in Form pharmazeutischer Präparate bei der Bekämpfung bzw. Verhütung von Bluthochdruck und Herzinsuffizienz verwendet werden. Sie können nach verschiedenen, an sich bekannten Verfahren hergestellt werden.
IPC 1-7
A61K 37/02; C07D 231/12; C07D 233/56; C07D 233/60; C07D 233/64; C07D 277/30; C07D 307/54; C07D 333/24; C07D 401/12; C07D 407/12; C07D 409/12
IPC 8 full level
A61K 31/16 (2006.01); A61K 31/165 (2006.01); A61K 31/215 (2006.01); A61K 31/22 (2006.01); A61K 31/415 (2006.01); A61K 31/425 (2006.01); A61K 31/426 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4418 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/535 (2006.01); A61P 9/00 (2006.01); A61P 9/04 (2006.01); A61P 9/12 (2006.01); C07C 317/44 (2006.01); C07C 317/50 (2006.01); C07C 323/51 (2006.01); C07D 207/08 (2006.01); C07D 207/12 (2006.01); C07D 211/22 (2006.01); C07D 213/40 (2006.01); C07D 213/53 (2006.01); C07D 213/56 (2006.01); C07D 231/12 (2006.01); C07D 233/54 (2006.01); C07D 233/56 (2006.01); C07D 233/58 (2006.01); C07D 233/60 (2006.01); C07D 233/61 (2006.01); C07D 233/64 (2006.01); C07D 277/20 (2006.01); C07D 277/30 (2006.01); C07D 295/088 (2006.01); C07D 295/185 (2006.01); C07D 295/205 (2006.01); C07D 307/54 (2006.01); C07D 317/24 (2006.01); C07D 333/24 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07D 521/00 (2006.01); C07H 15/12 (2006.01)
CPC (source: EP KR US)
A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/12 (2017.12 - EP); C07C 317/44 (2013.01 - EP US); C07C 317/50 (2013.01 - EP US); C07D 207/08 (2013.01 - EP US); C07D 207/12 (2013.01 - EP US); C07D 211/22 (2013.01 - EP US); C07D 213/40 (2013.01 - EP US); C07D 213/53 (2013.01 - EP US); C07D 213/56 (2013.01 - EP US); C07D 231/12 (2013.01 - EP US); C07D 233/56 (2013.01 - EP US); C07D 233/64 (2013.01 - EP US); C07D 249/08 (2013.01 - EP US); C07D 277/30 (2013.01 - EP US); C07D 295/088 (2013.01 - EP US); C07D 295/185 (2013.01 - EP US); C07D 295/205 (2013.01 - EP US); C07D 307/54 (2013.01 - EP US); C07D 317/24 (2013.01 - EP US); C07D 333/24 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 403/12 (2013.01 - EP US); C07D 405/12 (2013.01 - EP US); C07D 409/12 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US); C07K 5/06 (2013.01 - KR); C07C 2601/02 (2017.04 - EP US); C07C 2601/08 (2017.04 - EP US); C07C 2601/14 (2017.04 - EP US)
Citation (applicant)
- EP 0309841 A2 19890405 - MERCK PATENT GMBH [DE]
- EP 0416373 A2 19910313 - HOFFMANN LA ROCHE [CH]
- EP 0130266 A1 19850109 - STADELMANN ERNST GMBH [AT]
- EP 0229667 A2 19870722 - ABBOTT LAB [US]
- WO 8704349 A1 19870730 - DELLARIA JOSEPH, et al
- EP 0189203 A2 19860730 - ABBOTT LAB [US]
- EP 0332008 A2 19890913 - HOFFMANN LA ROCHE [CH]
- WO 8705302 A2 19870911 - UPJOHN CO [US]
- J. GEN. CHEM. USSR, vol. 40, 1970, pages 2488
- U. GEN. CHEM. USSR, vol. 40, 1970, pages 2488
- J. AM. CHEM. SOC., vol. 107, 1985, pages 7105
- POL. J. CHEM., vol. 54, no. 11-12, 1980, pages 2225
- J. BIOL. CHEM., vol. 171, 1947, pages 383
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU MC NL PT SE
DOCDB simple family (publication)
EP 0509354 A2 19921021; EP 0509354 A3 19930616; EP 0509354 B1 20000823; AT E195731 T1 20000915; AU 1478892 A 19921022; AU 659832 B2 19950601; CA 2064955 A1 19921018; DE 59209858 D1 20000928; ES 2150907 T3 20001216; FI 921718 A0 19920416; FI 921718 A 19921018; HU 9201224 D0 19920728; HU T62864 A 19930628; IE 921242 A1 19921021; IL 101561 A0 19921230; JP 2628820 B2 19970709; JP H05155847 A 19930622; KR 920019814 A 19921120; MX 9201736 A 19921001; NO 921520 D0 19920415; NO 921520 L 19921019; NZ 242311 A 19941222; PH 30697 A 19970916; TW 198712 B 19930121; US 5393875 A 19950228; UY 23402 A1 19921013
DOCDB simple family (application)
EP 92105879 A 19920406; AT 92105879 T 19920406; AU 1478892 A 19920409; CA 2064955 A 19920402; DE 59209858 T 19920406; ES 92105879 T 19920406; FI 921718 A 19920416; HU 9201224 A 19920410; IE 921242 A 19920416; IL 10156192 A 19920410; JP 12139592 A 19920415; KR 920006339 A 19920416; MX 9201736 A 19920414; NO 921520 A 19920415; NZ 24231192 A 19920410; PH 44203 A 19920413; TW 81102462 A 19920401; US 10095993 A 19930803; UY 23402 A 19920410