EP 0512865 A3 19921202 - NOVEL CHOLESTEROL LOWERING COMPOUNDS
Title (en)
NOVEL CHOLESTEROL LOWERING COMPOUNDS
Publication
Application
Priority
- US 69876691 A 19910510
- US 80560291 A 19911209
- US 86674992 A 19920415
Abstract (en)
[origin: EP0512865A2] Disclosed herein are compounds of structural formula (I) <CHEM> which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthetase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.
IPC 1-7
IPC 8 full level
C07D 493/08 (2006.01); C07H 19/01 (2006.01)
CPC (source: EP)
C07D 493/08 (2013.01); C07H 19/01 (2013.01)
Citation (search report)
- [A] EP 0259087 A2 19880309 - MERCK & CO INC [US]
- [XPD] US 5026554 A 19910625 - BARTIZAL KENNETH F [US], et al
- [XPD] EP 0450812 A1 19911009 - MERCK & CO INC [US]
- [XPD] EP 0475706 A1 19920318 - MERCK & CO INC [US]
- [XP] JOURNAL OF ANTIBIOTICS, vol. 45, no. 5, May 1992, TOKYO (JP) pages 639 - 647; M. J. DAWSON ET AL.: "The squalestatins, novel inhibitors of squalene synthese produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity."
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL PT SE
DOCDB simple family (publication)
EP 0512865 A2 19921111; EP 0512865 A3 19921202; AU 1908292 A 19921230; CA 2109523 A1 19921126; IE 921492 A1 19921118; IL 101810 A0 19921230; WO 9220336 A2 19921126; WO 9220336 A3 19930204; YU 49292 A 19950131
DOCDB simple family (application)
EP 92304187 A 19920508; AU 1908292 A 19920508; CA 2109523 A 19920508; IE 921492 A 19920701; IL 10181092 A 19920508; US 9203941 W 19920508; YU 49292 A 19920508