Global Patent Index - EP 0531436 A4

EP 0531436 A4 19930616 - SEQUENCE-SPECIFIC NONPHOTOACTIVATED CROSSLINKING AGENTS WHICH BIND TO THE MAJOR GROOVE OF DUPLEX DNA

Title (en)

SEQUENCE-SPECIFIC NONPHOTOACTIVATED CROSSLINKING AGENTS WHICH BIND TO THE MAJOR GROOVE OF DUPLEX DNA

Publication

EP 0531436 A4 19930616 (EN)

Application

EP 91911335 A 19910524

Priority

  • US 52934690 A 19900525
  • US 64065491 A 19910114

Abstract (en)

[origin: WO9118997A1] Agents which bind to the major groove of nucleic acid duplexes in a sequence-specific manner and are capable of forming covalent bonds with one or both strands of the duplex in the absence of light are useful therapeutic agents in the treatment of conditions mediated by duplex DNA. These agents are designed so that the reactivity of the crosslinking agent does not interfere with the sequence specificity of the agent which binds to the major groove. Thus, specific desired DNA duplexes can be targeted and their activity diminished or enhanced.

IPC 1-7

C12P 19/34; C12Q 1/00; C12Q 1/64; G01N 33/00; G01N 33/564; G01N 33/566

IPC 8 full level

A61K 48/00 (2006.01); C07H 21/00 (2006.01); C07H 21/04 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01)

CPC (source: EP)

C07H 21/00 (2013.01); C12Q 1/6813 (2013.01); C12Q 1/6839 (2013.01); C12Q 1/6876 (2013.01); C12Q 1/701 (2013.01); C12Q 1/706 (2013.01); C12Q 1/708 (2013.01)

Citation (search report)

  • [X] EP 0375408 A1 19900627 - BAYLOR COLLEGE MEDICINE [US]
  • [XP] WO 9015884 A1 19901227 - UNIV JOHNS HOPKINS [US]
  • [T] US 5112962 A 19920512 - LETSINGER ROBERT L [US], et al
  • [XD] FEBS LETTERS vol. 28, no. 2, February 1988, AMSTERDAM NL pages 273 - 276 O.S. FEDOROVA ET AL.
  • [XP] NUCLEIC ACIDS RESEARCH. vol. 19, no. 7, 11 April 1991, ARLINGTON, VIRGINIA US pages 1527 - 1532 R.H. ALUL ET AL.
  • [T] JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 113, 25 September 1991, WASHINGTON, DC US pages 7765 - 7766 J.-P. SHAW ET AL.
  • See references of WO 9118997A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

WO 9118997 A1 19911212; AU 7998491 A 19911231; CA 2083719 A1 19911126; EP 0531436 A1 19930317; EP 0531436 A4 19930616; JP H06502388 A 19940317

DOCDB simple family (application)

US 9103680 W 19910524; AU 7998491 A 19910524; CA 2083719 A 19910524; EP 91911335 A 19910524; JP 51084691 A 19910524