EP 0532591 A4 19930721 - ANALYTICAL ROTORS AND METHODS FOR ANALYSIS OF BIOLOGICAL FLUIDS

Title (en)

ANALYTICAL ROTORS AND METHODS FOR ANALYSIS OF BIOLOGICAL FLUIDS

Publication

EP 0532591 A4 19930721 (EN)

Application

EP 91910787 A 19910531

Priority

US 53252490 A 19900604
US 67876291 A 19910401
US 67882391 A 19910401
US 67882491 A 19910401

Abstract (en)

[origin: WO9118656A1] An analytical rotor (10) for separating cellular components from a biological sample includes a plurality of internal chambers and passages for combining the cell-free sample with one or more reagents and distributing the sample to a plurality of individual test wells (92). The chambers and passages necessary for separating cellular components from a sample such as whole blood include a measuring chamber (40), an overflow chamber (44), a separation chamber (60), and a reagent chamber (80). The measuring chamber (40) and overflow chamber (44) have capillary dimensions so that an initial volume of whole blood partitions therebetween, with the measuring chamber filling first to provide a preselected volume. The separation chamber (60) is located radially outward from both the measuring chamber (40) and the reagent chamber (80) so that spinning of the rotor causes both the reagent and the measured blood volume to flow outward into the separation chamber (60). A collection chamber (90) is formed to receive the plasma from the separation chamber (60). Further spinning of the rotor causes the plasma to flow radially outward into a plurality of test wells (92) formed around the periphery of the collection chamber (90). Testing of the separated plasma volumes may be performed without removing the plasma from the rotor.

IPC 1-7

B01D 21/26; G01N 21/07; B04B 5/04

IPC 8 full level

B04B 5/00 (2006.01); G01N 21/07 (2006.01); G01N 33/48 (2006.01); G01N 33/483 (2006.01); G01N 33/49 (2006.01); G01N 35/00 (2006.01); G01N 37/00 (2006.01)

CPC (source: EP)

G01N 21/07 (2013.01); G01N 33/491 (2013.01); B01L 2400/0406 (2013.01); G01N 2035/00237 (2013.01)

Citation (search report)

[X] EP 0245703 A2 19871119 - MILES LAB [US]
[X] EP 0251946 A1 19880107 - KIS PHOTO IND [FR]
[X] FR 2557815 A1 19850712 - FLUILOGIC SYSTEMS OY [FI]
[X] US 3899296 A 19750812 - MAILEN JAMES C, et al
See references of WO 9118656A1

Designated contracting state (EPC)

DE FR GB IT

DOCDB simple family (publication)

WO 9118656 A1 19911212; AU 8083891 A 19911231; CA 2082827 A1 19911205; CA 2082827 C 20011002; DE 69130986 D1 19990415; DE 69130986 T2 19990930; EP 0532591 A1 19930324; EP 0532591 A4 19930721; EP 0608006 A2 19940727; EP 0608006 A3 19951018; EP 0608006 B1 19990310; JP 3061414 B2 20000710; JP H05508709 A 19931202

DOCDB simple family (application)

US 9103840 W 19910531; AU 8083891 A 19910531; CA 2082827 A 19910531; DE 69130986 T 19910531; EP 91910787 A 19910531; EP 94104814 A 19910531; JP 51048491 A 19910531