Global Patent Index - EP 0533834 A4

EP 0533834 A4 19950419 -

Publication

EP 0533834 A4 19950419 (EN)

Application

EP 91912402 A 19910614

Priority

  • US 53885390 A 19900615
  • US 61931990 A 19901128
  • US 63239090 A 19901221
  • US 9104284 W 19910614
  • US 9103592 W 19910522

Abstract (en)

[origin: WO9119502A1] The present invention relates to compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions mediated by intercellular adhesion. Compositions which selectively bind a selectin receptor and which have at least one selectin-binding moiety are provided by the present invention. The selectin-binding moieties have the general formula: R1-Gal beta 1,4(Fuc alpha 1,3)GlcNAc-(R2)a wherein R1 is an oligosaccharide or R3-R4-C(CO2H)-, wherein R3 and R4 are the same or different and are -H, -C1-C8 alkyl, -hydroxyl C1-C8 alkyl, -aryl C1-C8 alkyl, or -alkoxy C1-C8 alkyl; wherein R2 is beta l, 3Gal, alpha 1, 2Man or alpha 1, 6GalNac and a is 0 or 1.

IPC 1-7

A61K 31/70; A61K 37/02; A61K 37/20; A61K 39/00

IPC 8 full level

A61K 9/127 (2006.01); A61K 31/70 (2006.01); A61K 31/715 (2006.01); A61K 35/12 (2006.01); A61K 38/00 (2006.01); A61K 38/13 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); A61K 47/48 (2006.01); C07H 3/06 (2006.01); C07H 15/04 (2006.01); C07H 15/10 (2006.01); C07K 16/18 (2006.01); C12N 9/10 (2006.01); G01N 33/569 (2006.01)

IPC 8 main group level

A61K (2006.01)

CPC (source: EP)

A61K 9/1271 (2013.01); A61K 31/70 (2013.01); A61K 31/715 (2013.01); A61K 38/13 (2013.01); A61K 47/543 (2017.07); A61K 47/549 (2017.07); A61K 47/6845 (2017.07); A61K 47/6911 (2017.07); C07H 3/06 (2013.01); C07H 15/04 (2013.01); C07H 15/10 (2013.01); C07K 16/18 (2013.01); C12N 9/1051 (2013.01); G01N 33/56972 (2013.01)

Citation (search report)

  • [XP] WO 9013300 A1 19901115 - BIOGEN INC [US]
  • [E] WO 9207572 A1 19920514 - UNIV MICHIGAN [US]
  • [XPD] M.TIEMEYER ET AL.: "Carbohydrate ligands for endothelial-leukocyte adhesion molecule 1", PROC.NATL.ACAD.SCI. U.S.A., vol. 88, February 1991 (1991-02-01), pages 1138 - 1142, XP000562666, DOI: doi:10.1073/pnas.88.4.1138
  • [X] P.H.JOHNSON ET AL.: "Sialyl compounds as acceptor substrates for the human alpha-3- and alpha-3/4-L-fucosyltransferases", BIOCHEM.SOC.TRANS., vol. 13, no. 6, 1985, pages 1119 - 1120
  • [XP] J.B.LOWE ET AL.: "ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltransferase cDNA", CELL, vol. 63, no. 3, 2 November 1990 (1990-11-02), pages 475 - 484, XP023907995, DOI: doi:10.1016/0092-8674(90)90444-J
  • [XP] M.L.PHILLIPS ET AL.: "ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Lex", SCIENCE, vol. 250, no. 4984, 23 November 1990 (1990-11-23), pages 1130 - 1132, XP000601651, DOI: doi:10.1126/science.1701274
  • [E] E.L.BERG ET AL.: "A Carbohydrate Domain Common to Both Sialyl Lea and Sialyl Lex Is Recognized by the Endothelial Cell Leukocyte Adhesion Moloecule ELAM-1", J.BIOL.CHEM., vol. 266, no. 23, 15 August 1991 (1991-08-15), pages 14869 - 14872, XP000652121
  • [E] D.TYRRELL ET AL.: "Structural requirements for the carbohydrate ligand of E-selectin", PROC.NATL.ACAD.SCI. U.S.A., vol. 88, no. 22, November 1991 (1991-11-01), pages 10372 - 10376, XP000562667, DOI: doi:10.1073/pnas.88.22.10372
  • [E] L.J.PICKER ET AL.: "The Neutrophil Selectin LECAM-1 Presents Carbohydrate Ligands to the Vascular Selectins ELAM-1 and GMP-140", CELL, vol. 66, no. 5, 6 September 1991 (1991-09-06), pages 921 - 933, XP023908303, DOI: doi:10.1016/0092-8674(91)90438-5
  • [XP] B.K.BRANDLEY ET AL.: "Carbohydrate Ligands of the LEC Cell Adhesion Molecules", CELL, vol. 63, 30 November 1990 (1990-11-30), pages 861 - 863, XP023908144, DOI: doi:10.1016/0092-8674(90)90487-Y
  • [A] C.UNDERHILL ET AL.: "THE ROLE OF HYALURONIC ACID IN INTERCELLULAR ADHESION OF CULTERED MOUSE CELLS", EXP.CELL RES., vol. 117, no. 1, 1978, pages 155 - 164, XP024790889, DOI: doi:10.1016/0014-4827(78)90438-X
  • [A] S.D.ROSEN ET AL.: "Lymphocyte attachment to high endothelial venules during recirculation: A possible role for carbohydrates as recognition determinants", MOL.CELL.BIOCHEM., vol. 72, no. 1-2, November 1986 (1986-11-01), pages 153 - 164
  • [A] DATABASE WPI Derwent World Patents Index; AN 90-135674
  • [AP] C.K.CHING ET AL.: "PURIFICATION AND CHARACTERIZATION OF A PEANUT-AGGLUTININ-BINDING PANCREATIC-CANCER-RELATED SERUM MUCUS GLYCOPROTEIN", J.CANCER, vol. 45, no. 6, 15 June 1990 (1990-06-15), pages 1022 - 1027, XP000605191, DOI: doi:10.1002/ijc.2910450607

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

WO 9119502 A1 19911226; AU 660931 B2 19950713; AU 8007791 A 19920107; AU 8102991 A 19920107; BR 9106556 A 19911226; CA 2084888 A1 19911216; EP 0533834 A1 19930331; EP 0533834 A4 19950419; FI 925668 A0 19921214; FI 925668 A 19921214; HU 216312 B 19990628; HU 9204091 D0 19931129; HU T69652 A 19950928; IE 912048 A1 19911218; IL 98493 A 19981206; NO 924830 D0 19921214; NO 924830 L 19930208; NZ 238556 A 19940126; SG 52563 A1 19980928; WO 9119501 A1 19911226

DOCDB simple family (application)

US 9104284 W 19910614; AU 8007791 A 19910522; AU 8102991 A 19910614; BR 9106556 A 19910614; CA 2084888 A 19910614; EP 91912402 A 19910614; FI 925668 A 19921214; HU 409192 A 19910614; IE 204891 A 19910614; IL 9849391 A 19910613; NO 924830 A 19921214; NZ 23855691 A 19910614; SG 1996006092 A 19910614; US 9103592 W 19910522