EP 0533837 A1 19930331 - INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES.
Title (en)
INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES.
Title (de)
HEMMUNG VON DURCH DEN 5-LIPOXYGENASE- UND CYCLOOXYGENASE WEG VERURSACHTEN ERKRANKUNGEN.
Title (fr)
INHIBITION DE MALADIES INDUITES PAR DES VOIES DE 5-LIPOXYGENASE ET DE CYCLOOXYGENASE.
Publication
Application
Priority
- US 53719590 A 19900612
- US 9104022 W 19910607
Abstract (en)
[origin: WO9119497A1] A method of dual inhibition of 5-lipoxygenase pathway mediated diseases and cyclooxygenase pathway mediated diseases in a subject in need thereof which comprises administering to such subject an effective, non-toxic 5-lipoxygenase pathway inhibiting amount or an effective, non-toxic cyclooxygenase pathway inhibiting amount of a diaryl-substituted imidazole fused to a second unsaturated 5 or 6 membered heterocyclic ring containing a nitrogen bridgehead atom wherein said second 5 membered ring also contains a sulfur or oxygen atom or said 6 membered ring may also contain an additional nitrogen atom.
Abstract (fr)
Procédé de double inhibition de maladies induites par des voies de 5-lipoxygénase et de maladies induites par des voies de cyclooxygénase chez un sujet nécessitant une telle inhibition, consistant à administrer audit sujet une dose efficace d'inhibition de voies de 5-lipoxygénase non toxique ou une dose efficace non toxique d'inhibition des voies de cyclooxygénase d'un imidazole à substitution diaryle fusionné à un second anneau hétérocyclique pentagonal ou hexagonal insaturé contenant un atome de tête de pont d'azote, ledit second anneau de pentagonal contenant également un atome de soufre ou d'oxygène ou ledit anneau de hexagonal contenant également un atome d'azote supplémentaire.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61K 31/44 (2006.01); A61K 31/445 (2006.01); A61K 31/505 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)
CPC (source: EP KR)
A61K 31/415 (2013.01 - KR); A61K 31/44 (2013.01 - EP); A61K 31/445 (2013.01 - EP); A61P 43/00 (2017.12 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9119497 A1 19911226; AU 8205991 A 19920107; CA 2084290 A1 19911213; EP 0533837 A1 19930331; EP 0533837 A4 19941117; IE 911977 A1 19911218; JP H05508153 A 19931118; KR 930700104 A 19930313; NZ 238485 A 19940325; PT 97960 A 19920331; ZA 914491 B 19921230
DOCDB simple family (application)
US 9104022 W 19910607; AU 8205991 A 19910607; CA 2084290 A 19910607; EP 91912750 A 19910607; IE 197791 A 19910611; JP 51207791 A 19910607; KR 920703188 A 19921211; NZ 23848591 A 19910611; PT 9796091 A 19910612; ZA 914491 A 19910610