EP 0533838 A4 19930526 - NUCLEIC ACID LIGANDS

Title (en)

NUCLEIC ACID LIGANDS

Publication

EP 0533838 A4 19930526 (EN)

Application

EP 91912753 A 19910610

Priority

US 53642890 A 19900611
US 9104078 W 19910610

Abstract (en)

[origin: EP1695978A1] A new class of nucleic acid compounds, referred to as nucleic acid antibodies, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the ligand components of the nucleic acid antibodies are identified by the method of the invention referred to as the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.

IPC 1-7

C12Q 1/68; C12P 19/34; G01N 33/48; G01N 33/566; C07H 15/12

IPC 8 full level

A61K 31/70 (2006.01); A61K 47/48 (2006.01); C07H 15/12 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07K 5/00 (2006.01); C07K 14/00 (2006.01); C07K 16/44 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/115 (2010.01); C12P 19/34 (2006.01); C12Q 1/37 (2006.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01); G01N 33/48 (2006.01); G01N 33/531 (2006.01); G01N 33/532 (2006.01); G01N 33/535 (2006.01); G01N 33/566 (2006.01); G01N 33/569 (2006.01); G01N 33/68 (2006.01); G01N 33/76 (2006.01); C07B 61/00 (2006.01); F02B 75/02 (2006.01)

CPC (source: EP US)

A61K 47/547 (2017.08 - EP US); A61K 47/549 (2017.08 - EP US); A61P 43/00 (2018.01 - EP); B82Y 5/00 (2013.01 - EP US); C07H 19/06 (2013.01 - EP US); C07H 19/10 (2013.01 - EP US); C07H 21/00 (2013.01 - EP US); C07K 14/001 (2013.01 - EP US); C12N 9/1276 (2013.01 - EP US); C12N 15/1048 (2013.01 - EP US); C12N 15/115 (2013.01 - EP US); C12Q 1/37 (2013.01 - EP US); C12Q 1/6804 (2013.01 - EP US); C12Q 1/6811 (2013.01 - EP US); C12Q 1/70 (2013.01 - EP US); G01N 33/531 (2013.01 - EP US); G01N 33/532 (2013.01 - EP US); G01N 33/535 (2013.01 - EP US); G01N 33/56988 (2013.01 - EP US); G01N 33/68 (2013.01 - EP US); G01N 33/6842 (2013.01 - EP US); G01N 33/76 (2013.01 - EP US); C12N 2310/13 (2013.01 - EP US); C12N 2310/322 (2013.01 - EP US); C12N 2310/53 (2013.01 - EP US); C40B 40/00 (2013.01 - EP US); F02B 2075/027 (2013.01 - EP US); G01N 2333/16 (2013.01 - EP US); G01N 2333/163 (2013.01 - EP US); G01N 2333/503 (2013.01 - EP US); G01N 2333/575 (2013.01 - EP US); G01N 2333/62 (2013.01 - EP US); G01N 2333/8125 (2013.01 - EP US); G01N 2333/96433 (2013.01 - EP US); G01N 2333/96436 (2013.01 - EP US); G01N 2333/96455 (2013.01 - EP US); G01N 2333/96486 (2013.01 - EP US); G01N 2333/966 (2013.01 - EP US); G01N 2333/9726 (2013.01 - EP US); G01N 2333/974 (2013.01 - EP US); G01N 2333/976 (2013.01 - EP US)

C-Set (source: EP US)

Citation (search report)

[E] WO 9205285 A1 19920402 - HUTCHINSON FRED CANCER RES [US]
[X] NUCLEIC ACIDS RESEARCH. vol. 17, no. 10, 1989, ARLINGTON, VIRGINIA US pages 3645 - 3653 K.W. KINZLER ET AL.
[XP] NUCLEIC ACIDS RESEARCH. vol. 18, no. 11, 11 June 1990, ARLINGTON, VIRGINIA US pages 3203 - 3209 H.-J. THIESEN ET AL.
[XP] SCIENCE vol. 249, 3 August 1990, LANCASTER, PA US pages 505 - 510 C. TUERK ET AL.

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

WO 9119813 A1 19911226; AT E160821 T1 19971215; AT E318832 T1 20060315; AU 663053 B2 19950928; AU 8206191 A 19920107; CA 2084987 A1 19911212; CA 2084987 C 20070213; DE 69128350 D1 19980115; DE 69128350 T2 19980326; DE 69133513 D1 20060427; DE 69133513 T2 20060921; DK 0533838 T3 19980223; DK 0786469 T3 20060710; EP 0533838 A1 19930331; EP 0533838 A4 19930526; EP 0533838 B1 19971203; EP 0786469 A2 19970730; EP 0786469 A3 19970806; EP 0786469 B1 20060301; EP 1493825 A2 20050105; EP 1493825 A3 20050209; EP 1695978 A1 20060830; ES 2110444 T3 19980216; ES 2259800 T3 20061016; GR 3025594 T3 19980331; IE 911979 A1 19911218; IE 980162 A1 20000223; IL 112141 A 19980405; IL 98456 A0 19920715; IL 98456 A 19970318; JP 2007195559 A 20070809; JP 2007195560 A 20070809; JP 2763958 B2 19980611; JP 4276272 B2 20090610; JP H05507413 A 19931028; JP H08252100 A 19961001; KR 970002255 B1 19970226; NZ 238492 A 19930727; RU 2198931 C2 20030220; US 2003157487 A1 20030821; US 2003198989 A1 20031023; US 5475096 A 19951212; US 5670637 A 19970923; US 5696249 A 19971209; US 5843653 A 19981201; US 6110900 A 20000829; US 6331398 B1 20011218; US 6933116 B2 20050823

DOCDB simple family (application)

US 9104078 W 19910610; AT 91912753 T 19910610; AT 97200035 T 19910610; AU 8206191 A 19910610; CA 2084987 A 19910610; DE 69128350 T 19910610; DE 69133513 T 19910610; DK 91912753 T 19910610; DK 97200035 T 19910610; EP 04017602 A 19910610; EP 05027853 A 19910610; EP 91912753 A 19910610; EP 97200035 A 19910610; ES 91912753 T 19910610; ES 97200035 T 19910610; GR 970402895 T 19971204; IE 197991 A 19910611; IE 980162 A 19910611; IL 11214191 A 19910611; IL 9845691 A 19910611; JP 2007075062 A 20070322; JP 2007075076 A 20070322; JP 51208091 A 19910610; JP 5474396 A 19960312; KR 920703193 A 19921211; NZ 23849291 A 19910611; RU 92016539 A 19910610; US 14319098 A 19980827; US 3798601 A 20011018; US 40808503 A 20030403; US 40944295 A 19950324; US 41211095 A 19950327; US 46960995 A 19950606; US 50234400 A 20000210; US 71413191 A 19910610