Global Patent Index - EP 0536119 A4

EP 0536119 A4 19930804 - IMMUNOREGULATORY AGENTS

Title (en)

IMMUNOREGULATORY AGENTS

Publication

EP 0536119 A4 19930804 (EN)

Application

EP 90912260 A 19900626

Priority

  • US 9003618 W 19900626
  • US 30944689 A 19890210

Abstract (en)

[origin: WO9200071A1] Specific aspects of the cellular and humoral immune system of a mammalian host are regulated by administering to the host a compound having a reactive immunoregulatory conformation whose precise three-dimensional structure is defined herein. Sorbinil, tolrestat, WF-3681, and the other immunoregulatory agents described herein possess this reactive conformation and so are therapeutically useful for inhibiting delayed-type hypersensitivity, T-cell proliferation, and B-cell antibody production, without altering the normal cellularity of the immmune system or the normal metabolites of the arachidonic acid pathway.

IPC 1-7

A61K 31/45; A61K 31/35

IPC 8 full level

A61K 31/195 (2006.01); A61K 31/34 (2006.01); A61K 31/35 (2006.01); A61K 31/352 (2006.01); A61K 31/415 (2006.01); A61K 31/4166 (2006.01); A61K 31/45 (2006.01); A61K 31/505 (2006.01); A61K 31/60 (2006.01); A61K 45/00 (2006.01); A61P 37/00 (2006.01); C07D 233/74 (2006.01); C07D 311/30 (2006.01); C07D 491/107 (2006.01)

CPC (source: EP)

A61K 31/195 (2013.01); A61K 31/34 (2013.01); A61K 31/415 (2013.01); A61P 37/00 (2017.12)

Citation (search report)

  • [X] EP 0256629 A2 19880224 - AMERICAN HOME PROD [US]
  • [EL] US 4966911 A 19901030 - CLARK JOHN I [US], et al
  • [X] CLIN.RES. vol. 34, no. 2, 1986, page 507A S.A.SMITH ET AL. 'AN ALDOSE REDUCTASE INHIBITOR INHIBITS INFLAMMATION'
  • [X] CLIN.RES. vol. 34, no. 1, 1986, page 48A S.A.SMITH ET AL. 'AN ALDOSE REDUCTASE INHIBITOR INHIBITS INFLAMMATION'
  • [A] J.MED.CHEM. vol. 29, 1986, pages 2347 - 2351 M.J.CERELLI ET AL. 'ANTIINFLAMMATORY AND ALDOSE REDUCTASE INHIBITORY ACTIVITY OF SOME TRICYCLIC ARYLACETIC ACIDS'
  • [A] INVEST.OPHTHALMOL.VISUAL SCI. no. SUPP, 1980, page 12 P.F.KADOR ET AL. 'ANTIALLERGY DRUGS AS ALDOSE REDUCTASE INHIBITORS'
  • See references of WO 9200071A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 9200071 A1 19920109; EP 0536119 A1 19930414; EP 0536119 A4 19930804; JP H05508386 A 19931125

DOCDB simple family (application)

US 9003618 W 19900626; EP 90912260 A 19900626; JP 51151290 A 19900626