EP 0536245 A1 19930414 - NOVEL, PROTRACTED INSULIN ANALOGUES.
Title (en)
NOVEL, PROTRACTED INSULIN ANALOGUES.
Title (de)
NEUARTIGE INSULINANALOGE MIT VERLÄNGERTE WIRKDAUER.
Title (fr)
NOUVEAUX ANALOGUES INSULINIQUES A EFFET PROLONGE.
Publication
Application
Priority
DK 155690 A 19900628
Abstract (en)
[origin: WO9200321A1] Human insulin analogues wherein at least one of the amino acid residues in position B1-B6 has been replaced by a Lys or Arg have a prolonged insulin action. Asn in position A21 may be replaced by another amino acid residue to increase the stability of the insulin analogue in acid solution. Furthermore B30 may be blocked by means of an amido or ester group.
Abstract (fr)
Analogues d'insuline humaine à effet insulinique prolongé dans lesquels au moins l'un des restes d'acide aminé en position B1-B6 est remplacé par un reste de lysine (Lys) ou d'arginine (Arg). On peut remplacer Asn en position A21 par un autre reste d'acide aminé de façon à augmenter la statilité de l'anlogue insulinique dans une solution acide. De plus, on peut bloquer la position B30 à l'aide d'un groupe amido ou ester.
IPC 1-7
IPC 8 full level
A61K 9/08 (2006.01); A61K 38/28 (2006.01); C07K 14/575 (2006.01); C07K 14/62 (2006.01); C12P 21/02 (2006.01); C12P 21/06 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/62 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9200321A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9200321 A1 19920109; AU 8054391 A 19920123; DK 155690 D0 19900628; EP 0536245 A1 19930414; IE 912247 A1 19920101; IL 98596 A0 19920715; JP H05508406 A 19931125; NZ 238718 A 19920625; PT 98124 A 19920430; ZA 914830 B 19920325
DOCDB simple family (application)
DK 9100167 W 19910621; AU 8054391 A 19910621; DK 155690 A 19900628; EP 91912264 A 19910621; IE 224791 A 19910627; IL 9859691 A 19910624; JP 51133591 A 19910621; NZ 23871891 A 19910626; PT 9812491 A 19910627; ZA 914830 A 19910624