EP 0537293 A4 19930908 - LIGAND FOR CD28 RECEPTOR ON B CELLS AND METHODS
Title (en)
LIGAND FOR CD28 RECEPTOR ON B CELLS AND METHODS
Publication
Application
Priority
- US 54798090 A 19900702
- US 72210191 A 19910627
Abstract (en)
[origin: WO9200092A1] The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C gamma 1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61P 37/00 (2006.01); C07K 14/00 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/569 (2006.01); G01N 33/577 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 37/00 (2017.12); C07K 14/705 (2013.01); C07K 14/70521 (2013.01); C07K 14/70532 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); G01N 33/56972 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/32 (2013.01); C07K 2319/75 (2013.01)
Citation (search report)
- WO 9005541 A1 19900531 - UNIV MICHIGAN [US], et al
- WO 9215671 A1 19920917 - CYTOMED INC [US]
- EP 0440373 A1 19910807 - BRISTOL MYERS SQUIBB CO [US]
- JOURNAL OF EXPERIMENTAL MEDICINE vol. 173, March 1991, pages 721 - 730 PETER S. LINSLEY ET AL. 'Binding to the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation'
- EUROPEAN JOURNAL OF IMMUNOLOGY vol. 21, May 1991, pages 1277 - 1282 NITIN K. DAMLE ET AL. 'Direct helper T-cell induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7'
- Proceedings of the National Academy of Sciences, USA, Volume 87, July 1990, LINSLEY et al., "T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1", pages 5031-5035, see entire document.
- See references of WO 9200092A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9200092 A1 19920109; CA 2086325 A1 19920103; CA 2086325 C 20101005; EP 0537293 A1 19930421; EP 0537293 A4 19930908; JP 2002186486 A 20020702; JP H06508501 A 19940929
DOCDB simple family (application)
US 9104682 W 19910701; CA 2086325 A 19910701; EP 91914867 A 19910701; JP 2001278438 A 20010913; JP 51362591 A 19910701