EP 0538367 A1 19930428 - DERIVATIVES OF PITUITARY POSTERIOR LOBE HORMONES.
Title (en)
DERIVATIVES OF PITUITARY POSTERIOR LOBE HORMONES.
Title (de)
DERIVATE VON HYPOPHYSEN-HINTERLAPPEN HORMONEN.
Title (fr)
DERIVES D'HORMONES DU LOBE PITUITAIRE POSTERIEUR.
Publication
Application
Priority
SE 9002384 A 19900709
Abstract (en)
[origin: WO9200996A1] Derivatives of pituitary posterior lobe hormones, more precisely new vasotocin derivatives, are disclosed. The new vasotocin derivatives are comprised by formula (I), wherein A = Mpa or Hmp, B = D-Tyr, D-Tyr(Et), D-Phe, D-Phe(p-Et) or D-Trp, C = Thr, Val or Hgn, D = Cys or alpha -Abu, E = Pro or a peptide bond, F = (a), wherein m = 0-6, n = 0-6, L = H, C00H, CO-NH2 or CH2-OH, K = H, (b) or a D- or L-amino acid residue with the proviso that L is not H when A is Mpa, C is Thr or Val and D is Cys. Further, pharmaceutical compositions including the new vasotocin derivatives and being preferably in a form suitable for intravenous, intranasal or intraintestinal administration, are described. The compositions are especially intended for use in the therapeutic treatment of excessive uterus muscle contractions.
Abstract (fr)
L'invention décrit des dérivés d'hormones du lobe pituitaire postérieur, plus précisément, de nouveaux dérivés de vasotocine. Les nouveaux dérivés de vasotocine correspondent à la formule (I), dans laquelle A = Mpa ou Hmp, B = D-Tyr, D-Tyr(Et), D-Phe, D-Phe(p-Et) ou D-Trp, C = Thr, Val ou Hgn, D = Cys ou alpha-Abu, E = Pro ou une liaison de peptide, F = (a), dans laquelle m = 0-6, n = 0-6, L = H, COOH, CO-NH2 ou CH2-OH, K = H, (b) ou un résidu d'acide aminé dans la mesure ou L n'est pas H quand A est Mpa, C est Thr ou Val et D est Cys. De plus, l'invention décrit, des compositions pharmaceutiques comprenant les nouveaux dérivés de vasotocine, de préférence sous forme appropriée à l'administration intraveineuse, intranasale ou intraintestinale. Les compositions sont particulièrement destinées au traitement thérapeutique des contractions excessives du muscle utérin.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/095 (2019.01); A61P 13/02 (2006.01); A61P 15/00 (2006.01); C07K 7/16 (2006.01)
CPC (source: EP)
A61P 13/02 (2017.12); A61P 15/00 (2017.12); C07K 7/16 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9200996A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9200996 A1 19920123; AU 8225191 A 19920204; CA 2085603 A1 19920110; EP 0538367 A1 19930428; FI 930013 A0 19930104; FI 930013 A 19930104; IE 912378 A1 19920115; IL 98737 A0 19920715; JP H05508849 A 19931209; MC 2291 A1 19930714; PL 297600 A1 19920713; SE 9002384 D0 19900709
DOCDB simple family (application)
SE 9100477 W 19910704; AU 8225191 A 19910704; CA 2085603 A 19910704; EP 91913318 A 19910704; FI 930013 A 19930104; IE 237891 A 19910708; IL 9873791 A 19910704; JP 51239991 A 19910704; MC 2291 D 19910704; PL 29760091 A 19910704; SE 9002384 A 19900709