EP 0538396 A4 19940413 -
Publication
Application
Priority
US 54945690 A 19900706
Abstract (en)
[origin: WO9200948A1] Compounds useful as inhibitors of retroviral proteases characterized by structure (I), wherein the X<1> groups may consist of 0 to 2 alpha -amino acid groups terminally substituted by hydrogen or one of a number of end groups, and the R<1> group can be selected from a wide variety of hydrocarbon radicals. Compounds which exhibit a protease activity inhibition constant Ki of less than 50 are desired.
IPC 1-7
IPC 8 full level
A61K 31/195 (2006.01); A61K 31/34 (2006.01); A61K 31/341 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/42 (2006.01); A61K 31/66 (2006.01); A61K 31/665 (2006.01); A61K 31/675 (2006.01); A61K 38/00 (2006.01); A61P 31/12 (2006.01); C07C 215/18 (2006.01); C07C 237/08 (2006.01); C07C 271/20 (2006.01); C07C 271/22 (2006.01); C07C 317/28 (2006.01); C07C 323/41 (2006.01); C07D 209/08 (2006.01); C07D 209/14 (2006.01); C07D 235/06 (2006.01); C07D 261/10 (2006.01); C07D 295/12 (2006.01); C07D 295/13 (2006.01); C07D 307/66 (2006.01); C07D 317/20 (2006.01); C07D 317/28 (2006.01); C07D 521/00 (2006.01); C07F 9/32 (2006.01); C07F 9/40 (2006.01); C07K 1/113 (2006.01); C07K 5/02 (2006.01); C07K 5/06 (2006.01); C07K 5/065 (2006.01); C07K 5/072 (2006.01); C07K 14/81 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); C07C 271/22 (2013.01); C07D 209/08 (2013.01); C07D 209/14 (2013.01); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 235/06 (2013.01); C07D 249/08 (2013.01); C07D 295/13 (2013.01); C07D 317/20 (2013.01); C07D 317/28 (2013.01); C07K 5/021 (2013.01); C07K 5/06026 (2013.01); C07K 5/06078 (2013.01); C07K 5/06104 (2013.01); C07K 5/06191 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [PX] EP 0428849 A2 19910529 - HOECHST AG [DE]
- [E] WO 9118866 A2 19911212 - DU PONT MERCK PHARMA [US]
- [X] A. DUREAULT ET AL: "Nucleophilic opening of chiral bis(aziridines): a route to enantiomerically pure alpha amino aldehydes or acids and polysubstituted piperidines", JOURNAL OF ORGANIC CHEMISTRY, vol. 54, no. 22, 1989, EASTON US, pages 5324 - 5330
- [X] L. VARGHA ET AL.: "1.2:5.6-Dianhydro-3.4-isopropyliden-d-sorbit und l-idit", CHEMISCHE BERICHTE, vol. 92, 1959, WEINHEIM DE, pages 2506 - 2515
- See references of WO 9200948A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9200948 A1 19920123; AU 8320691 A 19920204; EP 0538396 A1 19930428; EP 0538396 A4 19940413; IE 912379 A1 19920115; JP H06501681 A 19940224; MX 9100120 A 19920228; PT 98227 A 19920529; PT 98228 A 19930831; ZA 915271 B 19920527
DOCDB simple family (application)
US 9104756 W 19910703; AU 8320691 A 19910703; EP 91914409 A 19910703; IE 237991 A 19910708; JP 51332591 A 19910703; MX 9100120 A 19910708; PT 9822791 A 19910705; PT 9822891 A 19910705; ZA 915271 A 19910708