Global Patent Index - EP 0538398 A4

EP 0538398 A4 19931229 - TISSUE-DERIVED TUMOR GROWTH INHIBITORS, METHODS FOR PREPARATION AND USES THEREOF

Title (en)

TISSUE-DERIVED TUMOR GROWTH INHIBITORS, METHODS FOR PREPARATION AND USES THEREOF

Publication

EP 0538398 A4 19931229 (EN)

Application

EP 91914707 A 19910625

Priority

US 54334890 A 19900625

Abstract (en)

[origin: WO9200318A1] The present invention provides methods for producing and purifying proteins comprising TGF- beta 3 precursor, pro region of the TGF- beta 3 precursor and mature TGF- beta 3. Moreover, this invention also provides methods for producing and purifying novel homodimeric proteins with enhanced production and heightened therapeutic utility which comprises mutations, signal peptide deletions, and protease cleavage site substitutions.

IPC 1-7

C12N 15/12

IPC 8 full level

A61K 38/22 (2006.01); C07K 1/16 (2006.01); C07K 1/20 (2006.01); C07K 1/22 (2006.01); C07K 1/30 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/495 (2006.01); C07K 14/52 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C12N 15/09 (2006.01); C12P 21/00 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

C07K 14/495 (2013.01)

Citation (search report)

  • WO 8912101 A1 19891214 - GENENTECH INC [US]
  • WO 9014360 A1 19901129 - ONCOGENE SCIENCE INC [US]
  • EP 0161937 A2 19851121 - CELLTECH LTD [GB]
  • WO 8910971 A1 19891116 - US HEALTH [US]
  • WO 9108291 A2 19910613 - GENENTECH INC [US]
  • [Y] MOLECULAR ENDOCRINOLOGY vol. 3, no. 12, 1989, pages 1977 - 1986 J. GRAYCAR ET AL. 'Human transforming growth factor beta3'
  • [Y] PROC NATL ACAD. SCI USA vol. 85, 1988, pages 3555 - 3559 M. TYKOCINSKI ET AL. 'glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of DAF mRNA'
  • [Y] . BIOL. CHEM. vol. 262, no. 29, pages 14090 - 14099 M. O'CONNOR-MCCOURT ET AL. 'Latent transforming growth factor beta 3 in serum'
  • See references of WO 9200318A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

WO 9200318 A1 19920109; AU 659412 B2 19950518; AU 8395891 A 19920123; CA 2084992 A1 19911226; EP 0538398 A1 19930428; EP 0538398 A4 19931229; JP H05509320 A 19931222

DOCDB simple family (application)

US 9104541 W 19910625; AU 8395891 A 19910625; CA 2084992 A 19910625; EP 91914707 A 19910625; JP 51424291 A 19910625