EP 0539491 A4 19940323 -
Publication
Application
Priority
US 55376090 A 19900713
Abstract (en)
[origin: WO9200753A1] The present invention relates polypeptide analogs which have agonist or antagonist or tissue selection properties relative to parathyroid hormone (PTH), parathyroid hormone-like protein (PLP) or parathyroid-related protein (PTHrP). The serine amino acid at position 3, the glutamine amino acid at position 6, the histidine amino acid at position 9 or combinations thereof are substituted by other natural or synthetic amino acids. Preferably, a human PTH fragment of about 34 amino acids is sufficient for pharmacological activity. These polypeptides are useful as agonists or antagonists in the treatment of a human being for disease conditions of cancer, osteoporosis, hypercalcemia, or hyperparathyroid disease conditions. The invention also concerns a method of performing certain assays using the modified peptides, and based on the results of the assays falling within preset limits, selecting those modified peptides which shall be useful in the treatment of disease conditions.
IPC 1-7
IPC 8 full level
A61K 38/22 (2006.01); A61P 3/00 (2006.01); C07K 14/635 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); C07K 14/635 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9200753A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9200753 A1 19920123; AU 667662 B2 19960404; AU 8299091 A 19920204; CA 2087190 A1 19920114; EP 0539491 A1 19930505; EP 0539491 A4 19940323; JP H05509098 A 19931216
DOCDB simple family (application)
US 9104971 W 19910715; AU 8299091 A 19910715; CA 2087190 A 19910715; EP 91913697 A 19910715; JP 51307891 A 19910715