Title (en)

6-HALO- AND 2-AMINO-6-HALO-PURINE 2',3'-DIDEOXY NUCLEOSIDES AND THEIR USE AS ANTIVIRAL AGENTS.

Title (de)

6-HALO- UND 2-AMINO-6-HALO-PURIN-2',3'-DIDEOXY-NUKLEOSIDE UND IHRE VERWENDUNG ALS ANTIVIRALE AGENZIEN.

Title (fr)

6-HALO- ET 2-AMINO-6-HALO-PURINE 2',3'-DIDESOXY NUCLEOSIDES AINSI QUE LEUR EMPLOI EN TANT QU'AGENTS ANTIVIRAUX.

Publication

EP 0544668 A4 19930303 (EN)

Application

EP 91904744 A 19910208

Priority

US 47740690 A 19900209

Abstract (en)

[origin: WO9112260A1] Compositions containing 6 halo, 2',3'-dideoxynucleoside purines and 2 amino, 6 halo, 2',3'-dideoxy-nucleoside purines are useful for the treatment of viral infections. Particularly, these compounds are useful for preventing viral replication and cytotoxic effects of human immunodeficiency virus (HIV) and hepatitis B virus in humans infected by these viruses.

IPC 1-7

A61K 31/52; A61K 31/70; C07H 19/173

IPC 8 full level

A61K 31/52 (2006.01); A61K 31/675 (2006.01); A61P 31/12 (2006.01); A61P 37/04 (2006.01); C07D 473/00 (2006.01); C07D 473/40 (2006.01); C07F 9/09 (2006.01); C07F 9/6561 (2006.01); C07H 19/16 (2006.01)

CPC (source: EP)

A61P 31/12 (2017.12); A61P 37/04 (2017.12); C07D 473/00 (2013.01); C07H 19/16 (2013.01)

Citation (search report)

• [XP] WO 9006671 A2 19900628 - PALESE PETER M [US]
• [XP] GB 2228479 A 19900829 - SANYO KOKUSAKU PULP CO [JP]
• [XP] PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 87, no. 23, December 1990, pages 9426-9430, Washington, DC, US; T. SHIRASAKA et al.: "Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro"
• See references of WO 9112260A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

WO 9112260 A1 19910822; CA 2075490 A1 19910810; EP 0544668 A1 19930609; EP 0544668 A4 19930303; JP H05506211 A 19930916

DOCDB simple family (application)

US 9100886 W 19910208; CA 2075490 A 19910208; EP 91904744 A 19910208; JP 50454991 A 19910208