EP 0547172 A1 19930623 - REGULATION OF T-CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR.
Title (en)
REGULATION OF T-CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR.
Title (de)
REGULATION DES T-ZELL-PROLIFERATION VIA EINEM NEUEN 5HT1-A REZEPTOR.
Title (fr)
REGULATION DE LA PROLIFERATION DE LYMPHOCYTES T VIA UN NOUVEAU RECEPTEUR, LE 5HT1a.
Publication
Application
Priority
US 57871090 A 19900904
Abstract (en)
[origin: WO9204015A2] A method of regulating proliferation of activated T cells exhibiting a 5HT1a receptor by introducing a sufficient amount of agonists or antagonists to either increase or decrease T cell proliferation. The basis for regulating cell proliferation may be (1) via the 5HT receptor, (2) via serotonin synthesis inhibition and/or (3) via serotonin stimulation of CD8+ subpopulations of activated T cells.
Abstract (fr)
Le procédé décrit qui permet de réguler la prolifération de lymphocytes T activés présentant un récepteur de type 5HT1a, consiste à introduire une quantité suffisante d'agents agonistes ou antagonistes dans le but soit d'augmenter soit de diminuer la prolifération des lymphocytes T. Le moyen utilisé comme base de régulation de la prolifération des lymphocytes T peut être: (1) le récepteur 5HT, (2) l'inhibition de la synthèse de la sérotonine, et/ou (3) la stimulation par la sérotonine des sous-populations CD8+ de lymphocytes T activés.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/135 (2006.01); A61K 31/195 (2006.01); A61K 31/40 (2006.01); A61K 31/435 (2006.01); A61K 31/445 (2006.01); A61K 31/495 (2006.01); A61K 31/505 (2006.01); A61K 31/55 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/135 (2013.01); A61K 31/40 (2013.01); A61K 31/435 (2013.01); A61K 31/445 (2013.01); A61K 31/505 (2013.01); A61K 31/55 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 16/286 (2013.01); C07K 16/30 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9204015A2
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9204015 A2 19920319; WO 9204015 A3 19920416; AU 8499891 A 19920330; AU 8848291 A 19920330; CA 2090688 A1 19920305; CA 2090689 A1 19920305; EP 0547172 A1 19930623; EP 0555231 A1 19930818; JP H06500775 A 19940127; JP H06503816 A 19940428; WO 9204014 A2 19920319; WO 9204014 A3 19920514
DOCDB simple family (application)
US 9106176 W 19910904; AU 8499891 A 19910904; AU 8848291 A 19910904; CA 2090688 A 19910904; CA 2090689 A 19910904; EP 91915814 A 19910904; EP 91918533 A 19910904; JP 51469791 A 19910904; JP 51782091 A 19910904; US 9106175 W 19910904