EP 0565708 A4 19940315 - VACCINE AGAINST PATHOGENS OF MUCOSAE USING LIPOSOMES.
Title (en)
VACCINE AGAINST PATHOGENS OF MUCOSAE USING LIPOSOMES.
Title (de)
IMPFSTOFF GEGEN MUKOSAPATHOGENE UNTER VERWENDUNG VON LIPOSOMEN.
Title (fr)
VACCINS RECOURANT A DES LIPOSOMES, UTILISES CONTRE LES AGENTS PATHOGENES DES MUQUEUSES.
Publication
Application
Priority
DE 4136553 A 19911106
Abstract (en)
[origin: WO9308834A1] Lipopolysaccharide (LPS) and outer-membrane protein (OMP) preparations of Bordetella pertussis were incorporated into multilamellar liposomes composed of soya bean derived phospholipids. After oral or intranasal vaccination of mice with the coated liposomes, specific antibody responses were detected in lung washes. However, a specific IgA response to LPS could be detected after immunisation with only the OMP-coated liposomes and not with the LPS-coated liposomes suggesting adjuvant activity bestowed by the proteins. The OMP-coated liposomes were significantly more effective in inducing an immune response than the OMP preparation alone. Responses were highest when mice were given a booster 30 days after primary immunisation. The maximum response occurred 20 days after the booster but specific antibody could still be detected 75 days after secondary immunisation. These results suggest that this liposome antigen delivery system has potential in stimulating secretory antibody responses which may be necessary to effectively protect against infection from B. pertussis.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 39/00 (2006.01); A61K 39/10 (2006.01); A61P 31/04 (2006.01)
CPC (source: EP)
A61K 9/1271 (2013.01); A61K 39/099 (2013.01); A61P 31/04 (2017.12)
Citation (search report)
- [X] US 7532327 B2 20090512 - BLOOM SCOTT H [US], et al
- See references of WO 9308834A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI NL SE
DOCDB simple family (publication)
WO 9308834 A1 19930513; DE 4136553 A1 19930513; EP 0565708 A1 19931020; EP 0565708 A4 19940315; JP H06507420 A 19940825
DOCDB simple family (application)
US 9209591 W 19921105; DE 4136553 A 19911106; EP 92924345 A 19921105; JP 50875793 A 19921105