EP 0567967 B1 19960710 - Tritium-labelled fibrinogen-receptor-antagonists, their use and their production
Title (en)
Tritium-labelled fibrinogen-receptor-antagonists, their use and their production
Title (de)
Tritiumarkierte Fibrinogen-Rezeptor-Antagonisten, deren Verwendung und Verfahren zur ihrer Herstellung
Title (fr)
Composés marqués au tritium utilisé comme antagonistes de récepteur de fibrinogen et leur préparation
Publication
Application
Priority
- DE 4213930 A 19920428
- DE 4214245 A 19920430
Abstract (en)
[origin: EP0567967A1] The present invention relates to novel fibrinogen receptor antagonists labelled with a detectable atom, which have a comparable or higher affinity for the receptor than <125>I-fibrinogen and whose binding is not impaired by foreign proteins, in particular the tritium-labelled fibrinogen receptor antagonists according to Claim 3 which, in the presence of foreign protein, e.g. of albumin or of fibrinogen, have an affinity (KD) of less than 500 nM for the receptor, their use as ligands in the fibrinogen receptor binding test or for determination of the concentration of fibrinogen receptor antagonists, and to processes for their production.
IPC 1-7
C07D 401/12; A61K 31/395; C07D 207/263; C07D 207/08; C07D 233/72; C07D 233/32; C07D 249/12; C07D 285/10; C07D 403/06; C07D 211/34; C07C 257/18
IPC 8 full level
G01N 33/86 (2006.01); A61K 31/395 (2006.01); C07C 255/53 (2006.01); C07C 257/18 (2006.01); C07D 207/08 (2006.01); C07D 207/26 (2006.01); C07D 207/263 (2006.01); C07D 211/34 (2006.01); C07D 233/32 (2006.01); C07D 233/72 (2006.01); C07D 235/12 (2006.01); C07D 235/18 (2006.01); C07D 249/12 (2006.01); C07D 285/10 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01)
CPC (source: EP KR US)
A61K 31/40 (2013.01 - KR); A61K 31/4166 (2013.01 - KR); A61K 31/4196 (2013.01 - KR); A61K 31/506 (2013.01 - KR); C07C 255/53 (2013.01 - EP US); C07C 257/18 (2013.01 - EP US); C07D 207/26 (2013.01 - EP US); C07D 233/32 (2013.01 - EP US); C07D 235/12 (2013.01 - EP US); C07D 235/18 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 403/04 (2013.01 - EP US); C07C 2601/14 (2017.04 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
EP 0567967 A1 19931103; EP 0567967 B1 19960710; AT E140225 T1 19960715; AU 3715393 A 19931104; AU 670778 B2 19960801; CA 2094963 A1 19931029; DE 59303178 D1 19960814; DK 0567967 T3 19961118; ES 2092170 T3 19961116; FI 931881 A0 19930427; FI 931881 A 19931029; GR 3020740 T3 19961130; IL 105519 A0 19930818; JP H0650977 A 19940225; KR 940005271 A 19940321; MX 9302446 A 19940331; NO 180046 B 19961028; NO 180046 C 19970205; NO 931528 D0 19930427; NO 931528 L 19931029; NZ 247511 A 19950224; US 5677466 A 19971014
DOCDB simple family (application)
EP 93106725 A 19930426; AT 93106725 T 19930426; AU 3715393 A 19930427; CA 2094963 A 19930427; DE 59303178 T 19930426; DK 93106725 T 19930426; ES 93106725 T 19930426; FI 931881 A 19930427; GR 960402105 T 19960807; IL 10551993 A 19930427; JP 10078993 A 19930427; KR 930006959 A 19930426; MX 9302446 A 19930427; NO 931528 A 19930427; NZ 24751193 A 19930427; US 44766795 A 19950523