Global Patent Index - EP 0568631 A4

EP 0568631 A4 19950405 - MONOCLONAL ANTIBODIES TO ELAM-1 AND THEIR USES.

Title (en)

MONOCLONAL ANTIBODIES TO ELAM-1 AND THEIR USES.

Title (de)

MONOKLONALE ANTIKÖRPER GEGEN ELAM-1 UND DEREN VERWENDUNGEN.

Title (fr)

ANTICORPS MONOCLONAUX DESTINES A UN RECEPTEUR DE SURFACE CELLULAIRE (ELAM-1) ET UTILISATIONS DE CES DERNIERS.

Publication

EP 0568631 A4 19950405 (EN)

Application

EP 92905123 A 19920123

Priority

  • US 64587891 A 19910124
  • US 73303391 A 19910722

Abstract (en)

[origin: WO9212729A1] Compositions and methods are provided for inhibiting inflammatory and other disease responses mediated by ELAM-1. In particular, the present invention provides immunoglobulins which selectively bind functional epitopes on ELAM-1 and block adhesion of leukocytes to activated endothelial cells both in vitro and in vivo.

IPC 1-7

A61K 37/22; A61K 39/00; C07K 17/00

IPC 8 full level

A61K 9/127 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61P 29/00 (2006.01); C07K 16/28 (2006.01); C12N 5/12 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61K 47/6849 (2017.07); A61P 29/00 (2017.12); C07K 16/2854 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [DX] WO 9005786 A1 19900531 - BRIGHAM & WOMENS HOSPITAL [US], et al
  • [DX] WO 9013300 A1 19901115 - BIOGEN INC [US]
  • [X] C. BENJAMIN ET AL.: "A blocking monoclonal antibody to endothelial-leukocyte adhesion molecule-1 (ELAM1).", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 171, no. 1, 31 August 1990 (1990-08-31), DULUTH MN, USA, pages 348 - 353
  • [DA] N. GRABER ET AL.: "T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1.", THE JOURNAL OF IMMUNOLOGY, vol. 145, no. 3, 1 August 1990 (1990-08-01), BALTIMORE MD, USA, pages 819 - 830
  • [DA] S. WELLICOME ET AL.: "A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.", THE JOURNAL OF IMMUNOLOGY, vol. 144, no. 7, 1 April 1990 (1990-04-01), BALTIMORE MD, USA, pages 2558 - 2565
  • [DA] M. BEVILACQUA ET AL.: "Identification of an inducible endothelial-leukocyte adhesion molecule.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 84, no. 24, December 1987 (1987-12-01), WASHINGTON DC, USA, pages 9238 - 9242
  • See references of WO 9212729A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9212729 A1 19920806; AU 1269092 A 19920827; CA 2100681 A1 19920725; EP 0568631 A1 19931110; EP 0568631 A4 19950405; IE 920206 A1 19920729; IL 100764 A0 19920906; JP H06505253 A 19940616; NO 932672 D0 19930723; NO 932672 L 19930923; NZ 241399 A 19940627; OA 09809 A 19940415; SK 77393 A3 19941207

DOCDB simple family (application)

US 9200577 W 19920123; AU 1269092 A 19920123; CA 2100681 A 19920123; EP 92905123 A 19920123; IE 920206 A 19920123; IL 10076492 A 19920124; JP 50542792 A 19920123; NO 932672 A 19930723; NZ 24139992 A 19920124; OA 60394 A 19930722; SK 77393 A 19920123