Global Patent Index - EP 0572505 A4

EP 0572505 A4 19960828 - HUMAN PLATELET-DERIVED GROWTH FACTOR RECEPTORS

Title (en)

HUMAN PLATELET-DERIVED GROWTH FACTOR RECEPTORS

Publication

EP 0572505 A4 19960828 (EN)

Application

EP 92905958 A 19920131

Priority

US 65079491 A 19910131

Abstract (en)

[origin: WO9213870A1] DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the membrane of a mammalian cell. Peptide fragments with functions equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor are provided. The constructs can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity. Soluble fragments comprising PDGF receptor sequences are also provided, including important intracellular kinase insert sequences which interact with intracellular proteins.

IPC 1-7

C07H 21/00; C12N 5/00; C12N 15/00

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 38/55 (2006.01); A61K 45/00 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 17/02 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 16/28 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 9/24 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/48 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 17/02 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/71 (2013.01); C07K 16/2863 (2013.01); C12N 9/12 (2013.01); C12N 9/1205 (2013.01); C12Y 207/01137 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/33 (2013.01)

Citation (search report)

  • [X] EP 0327369 A2 19890809 - UNIV CALIFORNIA [US]
  • [X] MORRISON D. ET AL.: "Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor", CELL, vol. 58, August 1989 (1989-08-01), NA US, pages 649 - 657, XP002003832
  • [X] WILLIAMS L T: "Signal transduction by the platelet-derived growth factor receptor", SCIENCE, vol. 243, 1989, LANCASTER, PA US, pages 1564 - 1570, XP002003833
  • [PX] ESCOBEDO J A ET AL.: "A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine", MOLECULAR AND CELLULAR BIOLOGY, vol. 11, no. 2, February 1991 (1991-02-01), WASHINGTON US, pages 1125 - 1132, XP002003834
  • [X] KAZLAUSKAS A ET AL.: "Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase", EMBO JOURNAL, vol. 9, no. 10, 1990, EYNSHAM, OXFORD GB, pages 3279 - 3286, XP002003835
  • See references of WO 9213870A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9213870 A1 19920820; AU 1346792 A 19920907; AU 669328 B2 19960606; CA 2101632 A1 19920801; EP 0572505 A1 19931208; EP 0572505 A4 19960828; EP 0811685 A2 19971210; EP 0811685 A3 19980415; EP 0811686 A2 19971210; EP 0811686 A3 19980415; IE 920318 A1 19920729; JP 2002186490 A 20020702; JP 3710404 B2 20051026; JP H06505629 A 19940630; NZ 241479 A 19940927; SG 54230 A1 19981116

DOCDB simple family (application)

US 9200862 W 19920131; AU 1346792 A 19920131; CA 2101632 A 19920131; EP 92905958 A 19920131; EP 97201602 A 19920131; EP 97201609 A 19920131; IE 920318 A 19920130; JP 2001298110 A 20010927; JP 50629592 A 19920131; NZ 24147992 A 19920131; SG 1996005267 A 19920131