Global Patent Index - EP 0575339 A4

EP 0575339 A4 19950405 - ANALOGS OF ACIDIC FIBROBLAST GROWTH FACTOR HAVING ENHANCED STABILITY AND BIOLOGICAL ACTIVITY.

Title (en)

ANALOGS OF ACIDIC FIBROBLAST GROWTH FACTOR HAVING ENHANCED STABILITY AND BIOLOGICAL ACTIVITY.

Title (de)

ANALOGE DES AZIDEN FIBROBLASTEN-WACHSTUMSFAKTORS MIT ERHÖHTER STABILITÄT UND BIOLOGISCHER AKTIVITÄT.

Title (fr)

ANALOGUES DU FACTEUR DE CROISSANCE ACIDE DES FIBROBLASTES PRESENTANT UNE STABILITE ET UNE ACTIVITE BIOLOGIQUE AMELIOREES.

Publication

EP 0575339 A4 19950405 (EN)

Application

EP 92902895 A 19920717

Priority

US 63245690 A 19901218

Abstract (en)

[origin: WO9211360A1] Novel analogs of aFGF which are provided in accordance with the present invention. These analogs are more stable and exhibit greater biological activity in the absence of heparin than naturally occurring aFGF. Enhanced stability may be achieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in the naturally occurring aFGF molecule in the area of amino acids 90 to 97. The novel analogs of the present invention are especially useful in therapeutic applications.

IPC 1-7

C12N 15/00; A61K 31/00

IPC 8 full level

A61K 38/22 (2006.01); A61P 43/00 (2006.01); C07K 14/00 (2006.01); C07K 14/50 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01); C12R 1/19 (2006.01)

CPC (source: EP KR)

A61P 43/00 (2017.12 - EP); C07K 14/501 (2013.01 - EP); C12N 15/00 (2013.01 - KR); A61K 38/00 (2013.01 - EP)

Citation (search report)

  • [A] EP 0298723 A1 19890111 - BIOTECHNOLOGY RES ASS [US]
  • [DA] LESZCZYNSKI, J. & ROSE, G.: "Loops in globular proteins: a novel category of secondary structure", SCIENCE, vol. 234, 14 November 1986 (1986-11-14), LANCASTER, PA US, pages 849 - 855
  • [DA] BAIRD, A. ET AL.: "Receptor- and heparin-binding domains of basic fibroblast growth factor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, April 1988 (1988-04-01), WASHINGTON US, pages 2324 - 2328
  • [T] ARAKAWA, T. ET AL.: "PRODUCTION AND CHARACTERIZATION OF AN ANALOG OF ACIDIC FIBROBLAST GROWTH FACTOR WITH ENHANCED STABILITY AND BIOLOGICAL ACTIVITY.", PROTEIN ENG 6 (5). 1993. 541-546
  • See references of WO 9211360A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9211360 A1 19920709; AU 663067 B2 19950928; AU 9152491 A 19920722; CA 2098484 A1 19920619; EP 0575339 A1 19931229; EP 0575339 A4 19950405; IE 914393 A1 19920701; IL 100418 A0 19920906; JP H06503962 A 19940512; KR 930703439 A 19931130; NZ 241021 A 19931223

DOCDB simple family (application)

US 9109441 W 19911217; AU 9152491 A 19911217; CA 2098484 A 19911217; EP 92902895 A 19920717; IE 439391 A 19911217; IL 10041891 A 19911218; JP 50372092 A 19911217; KR 930701853 A 19930617; NZ 24102191 A 19911217