EP 0575500 A1 19931229 - HIV PROTEASE INHIBITORS.
Title (en)
HIV PROTEASE INHIBITORS.
Title (de)
HIV-PROTEASEINHIBITOREN.
Title (fr)
AGENTS INHIBITEURS DE PROTEASE DE L'HIV.
Publication
Application
Priority
US 66629291 A 19910308
Abstract (en)
[origin: WO9215319A1] The invention relates to HIV protease inhibitors wherein the compounds have a 2,4-dihydroxy isostere wherein the hydroxyl group in the 2-position is further substituted to create a tertiary alcohol. Also disclosed are pharmaceutically acceptable salts thereof, which inhibit HIV-I protease and are useful in the treatment of AIDS.
Abstract (fr)
L'invention se rapporte à des composés inhibiteurs de protéase de l'HIV (virus de l'immunodéficience hummaine), qui comprennent une isostère 2,4-dihydroxy dans laquelle le groupe hydroxyle en position 2 est encore substitué pour former un alcool tertiaire. L'invention décrit également des sels pharmaceutiquement acceptables de ces composés, qui inhibent la protéase de l'HIV-I et qui servent au traitement du SIDA.
IPC 1-7
IPC 8 full level
A61K 31/16 (2006.01); A61K 31/19 (2006.01); A61K 31/195 (2006.01); A61K 31/22 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07C 221/00 (2006.01); C07C 225/02 (2006.01); C07C 233/30 (2006.01); C07C 233/47 (2006.01); C07C 237/12 (2006.01); C07C 237/22 (2006.01); C07C 271/06 (2006.01); C07C 271/22 (2006.01); C07C 311/32 (2006.01); C07K 5/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 37/04 (2017.12); A61P 43/00 (2017.12); C07C 237/22 (2013.01); C07C 271/22 (2013.01); C07K 5/0207 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9215319 A1 19920917; EP 0575500 A1 19931229; EP 0575500 A4 19940601; JP H06505495 A 19940623
DOCDB simple family (application)
US 9201738 W 19920307; EP 92908310 A 19920307; JP 50826393 A 19920307