EP 0575526 A4 19940330 -
Publication
Application
Priority
- US 66595491 A 19910308
- US 82730292 A 19920129
Abstract (en)
[origin: EP0503537A1] A compound according to formula (I): <CHEM> wherein R is C1-C10 alkyl; phenyl or C7-C10 aralkyl; C2-C10 aklyl substituted with one or two substituents selected from the group consisting of OR1 and -NR2R3; C2-C10 alkyl interrupted by one or two oxygen atoms or by a member selected from the group consisting of -NR4-, cis -CH=CH, trans -CH=CH- and -C=C-, and optionally substituted with one or two hydroxy (OH) or -NR2R3 groups; and wherein R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, phenyl, C7-C10 aralkyl, -CHO, -COR5-, -COOR5, -S(O2)R5 and C2-C6 alkyl optionally substituted with -NR2R3; R2 and R3 are the same or different and are selected from the group consisting of hydrogen, C1-C10 alkyl, C7-C10 aralkyl, phenyl, C2-C10 alkyl substituted with one or two hydroxy (OH) groups, -CHO, -COR5, -COOR5, and -S(O2)R5, R2 and R3 taken together with the nitrogen atom to which they are bound form an ethyleneimine ring or a 5- or 6-membered aromatic or non-aromatic heterocyclic ring optionally containing another heteroatom selected from the group consisting of sulfur, oxygen and nitrogen, R2 is H and R3 is -C(=NH)NH2 or R2 is -C(=NH)NH2 and R3 is H; R4 is selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 hydroxyalkyl, C2-C10 alkyl substituted with -NR2R3, C7-C10 aralkyl, phenyl, -COR5, -COOR5 and -S(O2)R5; R5 is selected from the group consisting of C1-C10 alkyl, C7-C10 aralkyl, alpha -, beta -, or gamma -naphthyl, phenyl, o-, m-, or p-tolyl as free bases and their salts with pharmaceutically acceptable acids, have been found to have cytostatic and anti-tumor activity.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61K 31/473 (2006.01); A61K 31/535 (2006.01); A61P 35/00 (2006.01); C07D 221/06 (2006.01); C07D 221/08 (2006.01); C07D 401/14 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07D 221/08 (2013.01); C07D 401/14 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
- [Y] GB 2000029 A 19790104 - ALLIED CHEM
- [Y] US 4197249 A 19800408 - DURR FREDERICK E [US], et al
- [Y] M. CROISY-DELCEY ET AL: "Aminoalkylamino derivatives of dihydroxy-benzo[g]isoquinoline dione and of trihydroxy-naphtho[2,3-g]isoquinoline dione:synthesis and anti-tumor evaluation", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 1, January 1988 (1988-01-01), PARIS FR, pages 101 - 106
- See references of WO 9215300A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0503537 A1 19920916; EP 0503537 B1 19970514; AT E153018 T1 19970515; AU 1580392 A 19921006; AU 663494 B2 19951012; BR 9205740 A 19940927; CA 2104582 A1 19920917; CZ 184793 A3 19940615; CZ 286180 B6 20000216; DE 69219646 D1 19970619; DE 69219646 T2 19971002; DK 0503537 T3 19971215; EP 0575526 A1 19931229; EP 0575526 A4 19940330; ES 2104753 T3 19971016; FI 103575 B1 19990730; FI 103575 B 19990730; FI 933895 A0 19930907; FI 933895 A 19930907; GR 3024436 T3 19971128; HU 215967 B 19990329; HU T68649 A 19950728; IE 920754 A1 19920909; IL 102087 A 19960912; JP 3009465 B2 20000214; JP H06511230 A 19941215; KR 100193593 B1 19990615; MX 9201020 A 19931101; NZ 241868 A 19950526; RU 2129546 C1 19990427; SG 66252 A1 19990720; TW 201735 B 19930311; WO 9215300 A1 19920917
DOCDB simple family (application)
EP 92104004 A 19920309; AT 92104004 T 19920309; AU 1580392 A 19920309; BR 9205740 A 19920309; CA 2104582 A 19920309; CZ 184793 A 19920309; DE 69219646 T 19920309; DK 92104004 T 19920309; EP 92908816 A 19920309; ES 92104004 T 19920309; FI 933895 A 19930907; GR 970402079 T 19970813; HU 9302540 A 19920309; IE 920754 A 19920306; IL 10208792 A 19920603; JP 50823192 A 19920309; KR 930702688 A 19930908; MX 9201020 A 19920309; NZ 24186892 A 19920306; RU 93057572 A 19920309; SG 1996004917 A 19920309; TW 81101743 A 19920307; US 9201606 W 19920309