Global Patent Index - EP 0579747 A4

EP 0579747 A4 19940706 - METHOD OF MODULATING MAMMALIAN T-CELL RESPONSE

Title (en)

METHOD OF MODULATING MAMMALIAN T-CELL RESPONSE

Publication

EP 0579747 A4 19940706 (EN)

Application

EP 92910543 A 19920320

Priority

US 67363491 A 19910322

Abstract (en)

[origin: WO9216234A1] Methods of modulating mammalian T-cell response restricted by an MHC and methods of treating an MHC-linked disease in a mammal suspected of requiring such modulation or treatment, are provided by the invention. The methods comprise treating the mammal or contacting the T-cells respectively with an effective amount of a peptide, which peptide has an amino acid sequence substantially corresponding to at least a portion of the antigen recognition site of said MHC, or a peptide mimetic wherein said peptide or peptide mimetic is capable of binding with a T-cell antigen receptor which unbound T-cell antigen receptor is capable of recognizing said MHC bound to an antigen.

IPC 1-7

A61K 37/02

IPC 8 full level

A61K 38/00 (2006.01); A61P 37/00 (2006.01); C07K 14/74 (2006.01)

CPC (source: EP)

A61P 37/00 (2017.12); C07K 14/70539 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [PX] WO 9114701 A1 19911003 - UNIV LELAND STANFORD JUNIOR [US]
  • [X] T. MUNITZ ET AL.: "A peptide derived from the alpha-helical region of class I MHC blocks CTL engagement of the class I MHC molecule.", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 54, no. 1, 1989, COLD SPRING HARBOR NY, USA, pages 557 - 561
  • [DA] W. WILLIAMS ET AL.: "The antigen-major histocompatibility complex-T cell receptor interaction. A structural analysis.", IMMUNOLOGIC RESEARCH, vol. 7, no. 4, December 1988 (1988-12-01), BASEL, SWITZERLAND, pages 339 - 350
  • [PX] W. WILLIAMS ET AL.: "Modulation of T cell responses with MHC-derived peptides.", IMMUNOLOGIC RESEARCH, vol. 11, no. 1, March 1992 (1992-03-01), BASEL, SWITZERLAND, pages 11 - 23
  • See references of WO 9216234A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

DOCDB simple family (publication)

WO 9216234 A1 19921001; AU 1795092 A 19921021; AU 669329 B2 19960606; CA 2106567 A1 19920923; EP 0579747 A1 19940126; EP 0579747 A4 19940706; JP H06507630 A 19940901

DOCDB simple family (application)

US 9202419 W 19920320; AU 1795092 A 19920320; CA 2106567 A 19920320; EP 92910543 A 19920320; JP 51061992 A 19920320