EP 0580752 A4 19940824 - HUMAN BONE DERIVED INSULIN LIKE GROWTH FACTOR BINDING PROTEIN
Title (en)
HUMAN BONE DERIVED INSULIN LIKE GROWTH FACTOR BINDING PROTEIN
Publication
Application
Priority
US 68835391 A 19910419
Abstract (en)
[origin: WO9218154A1] Purified and isolated compositions of a binding protein for insulin-like growth factors (IGFs) I and II are provided. The binding protein, known as human bone derived IGF binding protein (hBD-IGFBP), potentiates the proliferative effects of IGF-II upon bone cells. Diagnostic assays are also provided for hBD-IGFBP, as well as pharmaceutical compositions and methods for treatment of bone disorders, wound healing, skin repair, and means for modulating IGF activity in bone.
IPC 1-7
IPC 8 full level
A61K 38/27 (2006.01); A61K 38/00 (2006.01); A61K 38/30 (2006.01); A61P 43/00 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 14/65 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP)
A61P 43/00 (2017.12); C07K 14/4743 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [X] ANDRESS, D. L. ET AL.: "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 176, no. 1, 15 April 1991 (1991-04-15), DULUTH, MINNESOTA US, pages 213 - 218
- [PX] BAUTISTA, C. M. ET AL.: "Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: A potential canditate for fixing IGF-II in human bone", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 176, no. 2, 30 April 1991 (1991-04-30), DULUTH, MINNESOTA US, pages 756 - 763
- See references of WO 9218154A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9218154 A1 19921029; AU 1784492 A 19921117; AU 658187 B2 19950406; CA 2107475 A1 19921020; CZ 219093 A3 19941215; CZ 283601 B6 19980513; EP 0580752 A1 19940202; EP 0580752 A4 19940824; FI 934588 A0 19931018; FI 934588 A 19931018; HU 9302942 D0 19940128; HU T70297 A 19950928; JP 2527896 B2 19960828; JP H06501270 A 19940210; KR 0129864 B1 19980409; NO 933742 L 19931018; RU 2114120 C1 19980627
DOCDB simple family (application)
US 9203122 W 19920415; AU 1784492 A 19920415; CA 2107475 A 19920415; CS 219093 A 19920415; EP 92910967 A 19920415; FI 934588 A 19931018; HU 9302942 A 19920415; JP 51006092 A 19920415; KR 930703181 A 19931019; NO 933742 A 19931018; RU 93058185 A 19920415