EP 0581500 A1 19940202 - Antibiotic carbapenem compounds.
Title (en)
Antibiotic carbapenem compounds.
Title (de)
Antibiotische Carbapenemverbindungen.
Title (fr)
Dérivés de carbapénème antibiotiques.
Publication
Application
Priority
- EP 93305607 A 19930716
- EP 92402105 A 19920721
Abstract (en)
The present invention relates to carbapenems and provides a compound of the formula (I) <CHEM> wherein: R<1> is i-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R<2> is hydrogen or C1-4alkyl; R<3> is hydrogen or C1-4alkyl; P' is of the formula: <CHEM> and one or two of A,B,C,D,E,F,G and H, are nitrogen and the remainder are CH; and P is bonded to the nitrogen of the linking carbamoyl group by a carbon atom, in either ring, is substituted by the carboxy group on a carbon atom, in either ring, and is optionally further substituted, by up to three substitutents, on a carbon atom, in either ring; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.
IPC 1-7
C07D 477/00; C07D 401/12; C07F 9/568; C07D 401/14; C07D 403/12; C07D 403/14; A61K 31/40
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/397 (2006.01); A61K 31/435 (2006.01); A61K 31/495 (2006.01); A61P 31/04 (2006.01); C07D 401/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/00 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 471/04 (2006.01); C07D 477/00 (2006.01); C07D 477/20 (2006.01); C07D 519/00 (2006.01); C07F 9/568 (2006.01)
CPC (source: EP KR US)
A61P 31/04 (2018.01 - EP); C07D 401/12 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 403/12 (2013.01 - EP KR US); C07D 403/14 (2013.01 - EP KR US); C07D 477/20 (2013.01 - EP KR US); C07F 9/568 (2013.01 - EP US)
Citation (search report)
- [A] EP 0126587 A1 19841128 - SUMITOMO CHEMICAL CO [JP]
- [A] EP 0443883 A1 19910828 - SANKYO CO [JP]
- [PA] WO 9217481 A1 19921015 - ICI PLC [GB], et al
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
EP 0581500 A1 19940202; EP 0581500 B1 19980909; AT E170859 T1 19980915; CA 2099818 A1 19940122; DE 69320895 D1 19981015; DE 69320895 T2 19990211; ES 2121585 T3 19981201; JP H06179674 A 19940628; KR 100278031 B1 20010201; KR 940002246 A 19940217; US 5441949 A 19950815
DOCDB simple family (application)
EP 93305607 A 19930716; AT 93305607 T 19930716; CA 2099818 A 19930705; DE 69320895 T 19930716; ES 93305607 T 19930716; JP 17790393 A 19930719; KR 930013543 A 19930719; US 30704894 A 19940916