EP 0586486 A1 19940316 - NOVEL DERIVATIVES OF THIOPYRANOPYRROLE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
Title (en)
NOVEL DERIVATIVES OF THIOPYRANOPYRROLE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
Title (de)
NEUE THIOPYRANOPYRROLE, IHRE HERSTELLUNG UND VERWENDUNG IN ARZNEIMITTELN.
Title (fr)
NOUVEAUX DERIVES DU THIOPYRANOPYRROLE, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT.
Publication
Application
Priority
FR 9106037 A 19910517
Abstract (en)
[origin: EP0514275A1] New thiopyranopyrrole derivatives of general formula (I) in which X is an oxygen atom or an NH radical, R1 is phenyl, which is optionally substituted, cyclohexadienyl, naphthyl or heterocyclyl, R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, and n is 0, 1 or 2, in their stereoisomeric forms and their mixtures, optionally their salts when they exist and their preparation. The new derivatives according to the invention are particularly advantageous as antagonists of substance P. <IMAGE>
Abstract (fr)
Nouveaux dérivés de thiopyranopyrrole de formule générale (I) dans laquelle X est un atome d'oxygène ou un radical NH, R1 est phényle éventuellement substitué, cyclohexadiényle, naphtyle, ou hétérocyclyle, R2 est H, halogène, OH, alcoyle, aminoalcoyle, alcoylaminoalcoyle, dialcoylaminoalcoyle, alcoyloxy, alcoylthio, acyloxy, carboxy, alcoyloxycarbonyle éventuellement substitué, benzyloxycarbonyle, amino ou acylamino, et n est 0, 1 ou 2, sous leurs formes stéréoisomères et leurs mélanges, éventuellement leurs sels lorsqu'ils existent et leur préparation. Les nouveaux dérivés selon l'invention sont particulièrement intéressants comme antagonistes de la substance P.
IPC 1-7
IPC 8 full level
A61K 31/40 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 29/00 (2006.01); A61P 37/08 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 9/12 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/08 (2017.12); A61P 29/00 (2017.12); A61P 37/08 (2017.12); C07D 495/04 (2013.01)
Citation (search report)
See references of WO 9220685A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0514275 A1 19921119; AU 1914092 A 19921230; AU 653033 B2 19940915; CA 2109296 A1 19921118; CZ 244993 A3 19940316; EP 0586486 A1 19940316; FI 935073 A0 19931116; FI 935073 A 19931116; FR 2676446 A1 19921120; FR 2676446 B1 19930806; HU 9303252 D0 19940328; HU T70490 A 19951030; IE 921543 A1 19921118; IL 101864 A0 19921230; JP H06507894 A 19940908; MX 9202289 A 19930201; NO 934146 D0 19931116; NO 934146 L 19931116; NZ 242737 A 19930625; SK 126993 A3 19941109; TW 201748 B 19930311; WO 9220685 A1 19921126; ZA 923513 B 19930224
DOCDB simple family (application)
EP 92401331 A 19920515; AU 1914092 A 19920515; CA 2109296 A 19920515; CS 244993 A 19920515; EP 92911395 A 19920515; FI 935073 A 19931116; FR 9106037 A 19910517; FR 9200431 W 19920515; HU 9303252 A 19920515; IE 921543 A 19920701; IL 10186492 A 19920514; JP 51126292 A 19920515; MX 9202289 A 19920515; NO 934146 A 19931116; NZ 24273792 A 19920514; SK 126993 A 19920515; TW 81103722 A 19920514; ZA 923513 A 19920514