Global Patent Index - EP 0587777 A4

EP 0587777 A4 19950510 - CEA-BINDING PROTEINS AND METHODS FOR THEIR ISOLATION AND USE.

Title (en)

CEA-BINDING PROTEINS AND METHODS FOR THEIR ISOLATION AND USE.

Title (de)

CEA-BINDENDE PROTEINE UND METHODEN IHRER ISOLATION UND VERWENDUNG.

Title (fr)

PROTEINES DE LIAISON D'ANTIGENE CARCINOEMBRYONNAIRE ET LEURS PROCEDES D'ISOLATION ET D'UTILISATION.

Publication

EP 0587777 A4 19950510 (EN)

Application

EP 92913689 A 19920522

Priority

  • US 70888591 A 19910531
  • US 70888891 A 19910531
  • US 71438691 A 19910531

Abstract (en)

[origin: WO9221364A1] Disclosed are proteins, or fragments thereof, that specifically bind carcinoembryonic antigen (CEA) in the presence of a divalent cation in vitro. Also disclosed are methods of isolating these and other proteins which bind CEA. In this method, a biological sample containing CEA and a CEA-binding protein (CBP) is provided and contacted with a divalent cation at a concentration and for a time sufficient to enable the binding of said CBP to CEA, thereby forming a CBP-CEA conjugate. The sample is then contacted with an adsorbent that binds CEA for a time sufficient to allow the conjugate to adsorb to the adsorbent. Any portions of the sample which have not adsorbed to the adsorbent are removed. The CBP is dissociated from the adsorbent-bound conjugate and collected.

IPC 1-7

A61K 37/02; C07K 3/02; C07K 3/12; C07K 15/06; C07K 15/28; G01N 33/53; G01N 33/58; G01N 33/68

IPC 8 full level

C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/30 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/47 (2013.01); C07K 14/705 (2013.01); C07K 16/30 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [A] WO 8908255 A1 19890908 - NEW ENGLAND DEACONESS HOSPITAL [US]
  • [A] US 4732862 A 19880322 - BARTORELLI ALBERTO [IT]
  • [A] BARTORELLI A., BIOMEDICINE AND PHARMACOTHERAPY, vol. 41, no. 1, 1987, pages 2 - 5
  • [A] THOMAS P., ET AL., FASEB JOURNAL, vol. 2, no. 4, 1988, BETHESDA, MD US, pages A623
  • [A] TOTH C.A., ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 171, no. 2, 1990, DULUTH, MINNESOTA US, pages 633 - 640
  • See references of WO 9221364A1

Designated contracting state (EPC)

CH DE FR GB IT LI NL SE

DOCDB simple family (publication)

WO 9221364 A1 19921210; AU 2158292 A 19930108; EP 0587777 A1 19940323; EP 0587777 A4 19950510

DOCDB simple family (application)

US 9204353 W 19920522; AU 2158292 A 19920522; EP 92913689 A 19920522