EP 0588852 A1 19940330 - IMMUNOSUPPRESSIVE AND TOLEROGENIC OLIGOSACCHARIDE DERIVATIVES.
Title (en)
IMMUNOSUPPRESSIVE AND TOLEROGENIC OLIGOSACCHARIDE DERIVATIVES.
Title (de)
IMMONOSUPPRESSIVE UND TOLEROGENE OLIGOSACCHARIDDERIVATE.
Title (fr)
DERIVES D'OLIGOSACCHARIDE IMMUNOSUPPRESSEURS ET TOLEROGENES.
Publication
Application
Priority
- US 71416191 A 19910610
- US 77125991 A 19911002
- US 88901792 A 19920526
Abstract (en)
[origin: WO9222662A1] Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound $g(b)Gal(1-4)$g(b)GlcNAc(1-3)$g(b)Gal(1-4)$g(b)GlcNAc-R. In particular, the methods of this invention provide for a multi-step synthesis wherein selective monofucosylation is accomplished on the 3-hydroxy group on only one of the GlcNAc units found in the $g(b)Gal(1-4)$g(b)GlcNAc(1-3)$g(b)Gal(1-4)$g(b)GlcNAc-R compound. In this step, monofucosylation is achieved by use of the $g(a)(1-3)fucosyltransferase.
Abstract (fr)
Cette invention concerne des procédés et des compositions pharmaceutiques permettant de supprimer des réponses immunitaires à médiation cellulaire telles que les réponses inflammatoires à médiation cellulaire. Dans les compositions et les procédés décrits dans cette invention on utilise des glycosides d'oligosaccharide.
IPC 1-7
IPC 8 full level
C07H 5/06 (2006.01); A61K 31/70 (2006.01); A61K 31/7008 (2006.01); A61K 31/7024 (2006.01); A61K 31/7028 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07H 3/06 (2006.01); C07H 13/06 (2006.01); C07H 15/04 (2006.01); C07H 19/10 (2006.01); C07H 19/20 (2006.01); C12P 19/26 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP US)
A61K 31/70 (2013.01 - EP); A61P 29/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); C07H 3/06 (2013.01 - EP); C07H 15/04 (2013.01 - EP); C07H 19/10 (2013.01 - EP); C07H 19/20 (2013.01 - EP); C12P 19/26 (2013.01 - EP); A61K 39/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
DOCDB simple family (publication)
WO 9222662 A1 19921223; CA 2110495 A1 19921223; CA 2110997 A1 19921223; EP 0588852 A1 19940330; EP 0591256 A1 19940413; JP H06510661 A 19941201; JP H07502011 A 19950302; WO 9222301 A1 19921223
DOCDB simple family (application)
CA 9200251 W 19920610; CA 2110495 A 19920609; CA 2110997 A 19920610; CA 9200244 W 19920609; EP 92911443 A 19920610; EP 92911470 A 19920609; JP 51119592 A 19920609; JP 51119992 A 19920610