EP 0590094 A1 19940406 - 4-ARYL-3-(HETEROARYLUREIDO)QUINOLINE DERIVATIVES.
Title (en)
4-ARYL-3-(HETEROARYLUREIDO)QUINOLINE DERIVATIVES.
Title (de)
4-ARYL-3-HETEROARYLUREIDOCHINOLINE DERIVATE.
Title (fr)
DERIVES DE 4-ARYLE-3-(HETEROARYLUREIDO)QUINOLINE.
Publication
Application
Priority
- US 9201801 W 19920316
- US 69232391 A 19910426
Abstract (en)
[origin: WO9219614A1] Compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein R<1>, R<2>, R<3>, R<4>, m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula (I) are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
Abstract (fr)
Composés de la formule (I) et sels pharmaceutiquement acceptables desdits composés, dans laquelle R1, R2, R3, R4, m, X et Q sont définis comme suit, et nouveaux intermédiaires utilisés dans la synthèse desdits composés. Lesdits composés de la formule (I) sont des inhibiteurs de la coenzyme acyle A: cholestérol acyltransférase (ACAT) et sont utiles en tant qu'agents hypolipidémiants et anti-athérosclérose.
IPC 1-7
IPC 8 full level
A61K 31/47 (2006.01); A61K 31/50 (2006.01); A61K 31/505 (2006.01); A61K 31/52 (2006.01); A61K 31/535 (2006.01); A61P 3/06 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07D 215/36 (2006.01); C07D 215/38 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); C12N 9/99 (2006.01)
CPC (source: EP)
A61P 3/06 (2017.12); A61P 9/10 (2017.12); A61P 43/00 (2017.12); C07D 215/36 (2013.01); C07D 215/38 (2013.01); C07D 401/12 (2013.01)
Citation (search report)
See references of WO 9219614A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
WO 9219614 A1 19921112; AU 1879792 A 19921221; BR 9205939 A 19940927; CA 2108014 A1 19921027; CN 1066068 A 19921111; CZ 395592 A3 19940216; DE 9290049 U1 19940105; EP 0590094 A1 19940406; FI 934710 A0 19931025; FI 934710 A 19931025; HU 9303025 D0 19940128; HU T65748 A 19940728; IE 921330 A1 19921104; IL 101627 A0 19921230; JP H06501025 A 19940127; JP H0776215 B2 19950816; MX 9201916 A 19921101; NO 933837 L 19931025; NZ 242493 A 19940826; PT 100426 A 19930831; TW 197436 B 19930101; YU 44592 A 19941228; ZA 922976 B 19931025
DOCDB simple family (application)
US 9201801 W 19920316; AU 1879792 A 19920316; BR 9205939 A 19920316; CA 2108014 A 19920316; CN 92103010 A 19920425; CS 395592 A 19920316; DE 9290049 U 19920316; EP 92923349 A 19920316; FI 934710 A 19931025; HU 9303025 A 19920316; IE 921330 A 19920424; IL 10162792 A 19920416; JP 51018692 A 19920316; MX 9201916 A 19920424; NO 933837 A 19931025; NZ 24249392 A 19920424; PT 10042692 A 19920424; TW 81102005 A 19920317; YU 44592 A 19920424; ZA 922976 A 19920324